摘要
目的:探讨桉柠蒎肠溶软胶囊联合异丙托溴胺对慢性阻塞性肺疾病患者ET-1、corin、adiponectin水平的影响作用。方法:选取2019年1月~2019年12月期间在我院呼吸内科确诊并进行治疗的102例COPD患者,根据数字法随机分为对照组与观察组,每组各51例;对照组在常规治疗基础上采用异丙托溴胺进行治疗,观察组在对照组基础上联合桉柠蒎肠溶软胶囊进行治疗;对两组患者治疗后的治疗效果、临床症状消失时间以及治疗前后血液中ET-1、corin、adiponectin、IL-6水平指标作出比较与分析。结果:两组患者经过治疗后,对照组有效率80.39%,观察组有效率94.12%,组间比较显示观察组有效率显著高于对照组;两组患者治疗后,观察组咳嗽消失时间、憋喘消失时间、哮鸣音消失时间和湿啰音消失时间显著短于对照组,组间比较观察组治疗效率更高;两组患者血清中ET-1、corin指标水平在治疗前比较无统计学差异,治疗后两组患者相关指标较治疗前比较均得到改善,组间比较,观察组改善效果更显著,差异具有统计学意义;两组患者血清中APN、IL-6指标水平在治疗前比较无统计学差异,治疗后两组患者相关指标较治疗前比较均得到改善,组间比较,观察组改善效果更显著,差异具有统计学意义。结论:桉柠蒎肠溶软胶囊联合异丙托溴胺在慢性阻塞性肺疾病患者的治疗中可有效改善患者呼吸功能以及血液相关指标,且安全有效,疗效确切。
Objective To explore the effect of eucalyptus glutamate enteric soft capsule combined with ipratropium bromide on the levels of ET-1,corin and adiponectin in patients with chronic obstructive pulmonary disease.Methods 102 patients with COPD diagnosed and treated in our department of respiratory medicine from January 2019 to December 2019 were randomly divided into a control group and an observation group,each with 51 cases;the control group was routinely The treatment group was treated with ipratropium bromide,and the observation group was combined with eucalyptus tincture enteric-coated soft capsules on the basis of the control group;after treatment,the treatment effect,clinical symptoms disappeared time,and ET in blood before and after treatment-1.Corin,adiponectin,and IL-6 level indicators are compared and analyzed.Results After treatment in the two groups,the effective rate in the control group was 80.39%and the effective rate in the observation group was 94.12%.Comparison between the groups showed that the effective rate in the observation group was significantly higher than that in the control group.Cough disappearance time,wheezing disappearance time,wheezing sound disappearance time and wet wheezing sound disappearance time were significantly shorter than those in the control group,and the treatment efficiency between the observation group was higher;ET-1,Corin index levels were not statistically different before treatment.After treatment,the relevant indicators of the two groups of patients were improved compared to before treatment.Comparing the groups,the observation group had a more significant improvement effect.The difference was significant.Statistical significance;the serum levels of APN and IL-6 in the two groups of patients were not statistically different before treatment,and the relevant indicators of the two groups of patients were improved after treatment compared with that before treatment.Comparing the groups,the improvement effect in the observation group was more significant,and the difference was statistically significant.Conclusion Eucalyptus tincture enteric-coated soft capsule combined with ipratropium bromide can effectively improve patients’respiratory function and blood-related indicators in the treatment of chronic obstructive pulmonary disease,and it is safe,effective and effective.
作者
武俊慧
柴海强
Wu Jun-hui;Chai Hai-qiang(Department of Respiratory Medicine,Xi'an International Medical Center Hospital,Xi’an 710100,China)
出处
《湖南师范大学学报（医学版）》
2021年第4期244-247,共4页
Journal of Hunan Normal University(Medical Sciences)
关键词
桉柠蒎肠溶软胶囊
异丙托溴胺
慢性阻塞性肺疾病
eucalyptus tincture enteric-coated soft capsule
ipratropium bromide
chronic obstructive pulmonary disease
