摘要
目的:探讨氯氮平和奎硫平对首发精神分裂症患者的治疗效果及对体质量、血糖及瘦素的影响。方法:选取2014年1月~2016年1月在我院确诊的90例首发精神分裂症患者,采用前瞻性随机研究方法分为氯氮平组、喹硫平组各45例,对比两组治疗效果及对患者体质量、血糖及血清瘦素的影响。结果:治疗后,两组患者的PANSS总分、阴性症状量表、阳性症状量表、精神病理症状量表评分较治疗前均显著的降低,两组间比较差异均无统计学意义;治疗前,氯氮平组和喹硫平组的体质量、空腹血糖、瘦素差异无统计学意义;治疗后,氯氮平组的体质量、空腹血糖、瘦素均高于喹硫平组;氯氮平组治疗过程中的体重增加率、嗜睡发生率、便秘发生率、唾液分泌增多发生率均高于喹硫平组。结论:奎硫平对首发精神分裂症患者的治疗效果可靠,同时对患者的体重、空腹血糖、瘦素影响更小,安全性较高。
Objective To investigate the effects of clozapine and quetiapine in the treatment of patients with first-episode schizophrenia and effect on blood glucose and body weight,leptin.Methods From January 2014 to January 2016 in our hospital diagnosed 90 cases of patients with first-episode schizophrenia,a prospective randomized study method divided into clozapine group,quetiapine group 45 cases,compared two groups of treatment effect and influence on body weight,blood glucose and serum leptin.Results After treatment,the two groups of patients with PANSS score,negative symptom scale,positive symptom scale,psychiatric symptoms scale score were significantly decreased,the difference between the two groups had no statistical significance;before treatment,no significant clozapine group and quetiapine group body weight,fasting blood glucose,leptin difference;after treatment with clozapine group body weight,fasting blood glucose,leptin were higher than those in the quetiapine group;the treatment process of clozapine group in weight gain rate,incidence of somnolence,constipation incidence,hypersalivation were higher than the quetiapine group.Conclusion Quetiapine in the treatment of patients with first-episode schizophrenia and reliable effect,while patients with body weight,fasting blood glucose,leptin effects smaller,higher security.
作者
罗利玲
刘桂萍
黎爱云
Luo Li-ling;Liu Gui-ping;Li Ai-yun(Department of Psychosomatic Medicine,the Fourth People’s Hospital of Shaanxi Province,Xi’an 710043,China)
出处
《湖南师范大学学报（医学版）》
2020年第1期101-104,共4页
Journal of Hunan Normal University(Medical Sciences)
关键词
氯氮平
奎硫平
首发
精神分裂症
体质量
血糖
瘦素
quetiapine
clozapine
starting
schizophrenia
body weight
blood glucose
leptin
