摘要
目的明确新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)康复者14 d隔离观察期内血清维生素D水平与抑郁情绪的相关性,并探讨其中是否涉及甲状腺自身免疫学机制。方法对所有刚结束治疗并转入隔离观察病房的COVID-19患者进行网络问卷调查及空腹静脉血采样,以Zung氏抑郁自评量表分析抑郁情况,测定血清维生素D、甲状腺自身免疫性抗体。结果共95名对象纳入研究,其维生素D水平较健康对照组低[(38.5±7.1)ng/ml vs.(43.7±5.7)ng/ml,P<0.01];40%患者存在抑郁情绪,10.5%患者维生素D不足,维生素D不足者抑郁发生风险显著增加(OR=14.129,P<0.01),且抑郁自评得分更高[(46.3±6.7)分vs.(36.9±10.7),P<0.05]。维生素D不足、抑郁情绪均与甲状腺自身免疫性抗体无显著相关性。结论维生素D水平低于30 ng/ml是隔离观察期COVID-19康复者抑郁情绪的独立危险因素,不涉及甲状腺自身免疫机制,维生素D不足与抑郁情绪是否为因果关系待随机队列研究进一步明确。
Objective To determine the correlation between serum vitamin D level and depression in the coronavirus disease 2019(COVID-19)survivors in 14-day quarantine,and explore whether vitamin D affects depression through thyroid autoimmune mechanism.Methods All COVID-19 survivors after discharge immediately were investigated by online questionnaire and their fasting venous blood samples were taken.The depression status was analyzed by Zung’s self-rating depression scale(SDS).Serum vitamin D concentration and thyroid autoimmune antibodies were measured.Results A total of 95 subjects were enrolled,of whom the level of vitamin D was lower than that of the healthy control group[(38.5±7.1)ng/ml vs.(43.7±5.7)ng/ml,P<0.01)].About 40%of the subjects met the cutoff value of self-report depression,10.5%of the subjects were vitamin D deficient.Vitamin D deficiency was an independent risk factor for depression after COVID-19 infection(OR=14.12,P<0.01),and was also significantly associated with the score of SDS[(46.3±6.7)vs.(36.9±10.7),P<0.05].There was no significant correlation between vitamin D deficiency and thyroid autoimmune antibodies,neither between self-reported depression and thyoid autoimmune antibodies.Conclusion Vitamin D concentration below 30 ng/ml is an independent risk factor for self-report depression and is closely related to the severity of depression.Whether there is a causal relationship between vitamin D deficiency and depression remains to be further clarified by randomized cohort study.
作者
袁波
王建春
陈敏
孙微
胡小鹏
安亚文
李志文
陈子龙
陈小彦
于萍
蔡新
YUAN Bo;WANG Jianchun;CHEN Min;SUN Wei;HU Xiaopeng;AN Yawen;LI Zhiwen;CHEN Zilong;CHEN Xiaoyan;YU Ping;CAI Xin(Department of Neurology,Shenzhen Samii Medical Center,Shenzhen Guangdong518118,China)
出处
《华南国防医学杂志》
CAS
2020年第6期416-419,429,共5页
Military Medical Journal of South China
