摘要
目的探析18 F-脱氧葡萄糖(fluorodeoxyglucose,FDG)正电子发射计算机断层扫描显像(Positron Emission Computed Tomography,PET-CT)在非小细胞肺癌(non-small cell lung cancer,NSCLC)诊断中的应用。方法选择2020年6月-2022年5月就诊的89例NSCLC患者,所有患者均行(18)F-FDG PET-CT诊断。根据病理结果纵隔淋巴结(Mediastinal Lymph Node,MLN)是否转移分为转移组、未转移组。对比转移组、未转移组临床特征、影像学定量参数;对比不同分期患者的影像学定量参数;采用logistic回归模型分析MLN转移多影响因素。结果89例NSCLC患者中,未转移组51例,转移组38例。MLN转移、未转移患者的性别、原发病灶侧、病理类型、T分期特征对比,差异无统计学意义(P>0.05),而转移组原发病灶最大径高于未转移组,年龄低于未转移组(P<0.05)。转移组患者病灶淋巴结短径、病灶最大标准摄取值(maximum standardized uptake value,SUVmax)、淋巴结SUVmax均高于未转移组(P<0.05)两组原发病灶SUVmax/纵隔血池SUVmax对比差异无统计学意义(P>0.05)。高分期(ⅢⅣ期)、低分期(ⅠⅡ期)患者病灶SUVmax、CT、SUVmax/CT对比差异无统计学意义(P>0.05)。多因素logistic结果显示,年龄(OR=4.302,95%CI=1.118-6.773)、病灶SUVmax(OR=12.047,95%CI=4.125-17.548)、淋巴结SUVmax(OR=7.862,95%CI=3.734-9.011)均为MLN转移的危险因素(P<0.05)。结论(18)F-FDG PET-CT应用于NSCLC分期诊断及淋巴结诊断效能较好,(18)F-FDG PET-CT代谢参数病灶SUVmax、淋巴结SUVmax可作为预测淋巴结转移指标。
Objective To explore the application of 18 F-deoxyglucose(FDG)positron emission computed tomography(PET-CT)in the diagnosis of non-small cell lung cancer(NSCLC).Methods 89 patients with NSCLC from June 2020 to may 2022 were selected.All patients were diagnosed by(18)F-FDG PET-CT.According to the pathological results,mediastinal lymph node(MLN)was divided into metastasis group and non metastasis group.The clinical characteristics and imaging quantitative parameters of metastatic group and non metastatic group were compared;The quantitative imaging parameters of patients at different stages were compared;Logistic regression model was used to analyze the multiple influencing factors of mln metastasis.Results Among the 89 patients with NSCLC,51 were in the non metastasis group and 38 in the metastasis group.There was no significant difference between mln metastatic and non metastatic patients in terms of gender,primary lesion side,pathological type and T-stage characteristics(P>0.05),while the maximum diameter of primary lesion in the metastatic group was higher than that in the non metastatic group,and the age was lower than that in the non metastatic group(P<0.05).The short diameter of lymph nodes,maximum standardized uptake value(SUVmax)and SUVmax of lymph nodes in the metastasis group were higher than those in the non metastasis group(P<0.05).There was no significant difference between the two groups in the comparison of SUVmax of primary lesions/SUVmax of mediastinal blood pool(P>0.05).There was no significant difference in SUVmax,CT and suvmax/ct between patients with high stage(stage iiiiv)and low stage(stage iii)(P>0.05).Multivariate logistic results showed that age(OR=4.302,95%CI=1.118-6.773),SUVmax of lesions(OR=12.047,95%CI=4.125-17.548)and SUVmax of lymph nodes(OR=7.862,95%CI=3.734-9.011)were all risk factors for mln metastasis(P<0.05).Conclusions(18)F-FDG PET-CT is effective in staging diagnosis and lymph node diagnosis of NSCLC,(18)F-FDG PET-CT metabolic parameters SUVmax of focus and SUVmax of lymph node can be used as indicators to predict lymph node metastasis,which is worthy of clinical promotion.
作者
张龙敏
ZHANG Long-min(Department of Nuclear Medicine,Nanyang Central Hospital,Nanyang 473000,China)
出处
《航空航天医学杂志》
2022年第10期1159-1162,共4页
Journal of Aerospace medicine
