摘要
目的探讨广州市成人血脂异常与全血中砷(As)和铅(Pb)等7种金属的关联性。方法采取社区招纳方法,选取广州市的成人245人,对其进行健康体检、血液检查和问卷调查。检测全血中铬(Cr)、钴(Co)、砷(As)、钼(Mo)、镉(Cd)、锑(Sb)和铅(Pb)7种金属水平。结果血脂异常组As和Pb的中位数分别为2.39μg/L和27.48μg/L,均高于血脂正常组的1.90μg/L和20.85μg/L,差异有统计学意义(P<0.05)。其他5种金属在两组间差异均无统计学意义(P>0.05)。二分类logistics回归分析结果显示,未婚(OR=0.295,95%CI:0.095~0.920,P=0.035)可减少血脂异常的发生风险;年龄(OR=1.036,95%CI:1.013~1.059,P=0.002)、腰围(OR=1.025,95%CI:1.004~1.047,P=0.020)、As(OR=1.350,95%CI:1.068~1.705,P=0.012)和Pb(OR=1.031,95%CI:1.004~1.057,P=0.021)升高可增加血脂异常的发生风险。结论成人的血脂代谢异常与全血中的砷和铅浓度有关,提示需要关注成人体内的重金属水平。
Objective To explore the correlation between dyslipidemia and the concentrations of arsenic(As)and lead(Pb)and seven other metals in whole blood of adult in Guangzhou.Methods Adopt community recruitment approach and 245 adults were in our study for physical examination,blood examination and questionnaire survey.Chromium(Cr),cobalt(Co),arsenic(As),molybdenum(Mo),cadmium(Cd),antimony(Sb)and lead(Pb)were detected in whole blood.Results The median values of As and Pb in dyslipidemia group were 2.39μg/L and 27.48μg/L,in respectively,which were higher than those in normal group(1.90μg/L and 20.85μg/L).There was no significant difference in the other 5 metals between the two groups.Logistic regression analysis showed that age(1.036,1.013-1.059),waist circumference(1.025,1.004-1.047),As(1.350,1.068-1.705)and Pb(1.031,1.004-1.057)increased,which increased the risk of dyslipidemia.And being unmarried(0.295,0.095-0.920)can reduce the risk of dyslipidemia.Conclusion Abnormal blood lipid metabolism in adults was related to the concentration of arsenic and lead in whole blood,which suggested that we should be paid attention to heavy metal levels in adults.
作者
周金华
李琴
黎晓彤
黄仁德
毕华
郭重山
ZHOU Jin-hua;LI Qin;LI Xiao-tong;HUANG Ren-de;BI Hua;GUO Chong-shan(Department of Disinfection and Vector Control,Guangzhou Center for Disease Control and Prevention,Guangzhou,Guangdong 510440,China;不详)
出处
《环境与健康杂志》
CAS
2024年第1期44-47,共4页
Journal of Environment and Health
基金
广东省医学科研基金(B2022264)
广东省基础与应用基础研究基金(2021A1515110611)
关键词
金属
重
砷
铅
血脂异常
Metal,heavy
Arsenic
Lead
Dyslipidaemia
