摘要
胚胎干细胞(Embryonic stem cells,ESCs)是一类具有无限增殖、自我更新和多向分化潜能的细胞。ESCs广泛应用于转基因动物生产、人类疾病模型构建、濒危物种保护、人体器官移植及细胞分化等方面的研究。ESCs结合基因编辑技术生产大型动物模型在生物医学领域中得到了广泛应用,在动物育种方面不仅改善了动物生产特性和抗病能力,还可生产出具有更高价值和更高品质的产品,展现出良好的社会价值和应用前景。本研究对ESCs的研究现状、动物育种中的应用及前景作简要综述。
Embryonic stem cells(ESCs)are a type of cells with the potential for immortal proliferation,self-renewal and multidirectional differentiation.ESCs are widely used in research on transgenic animal production,human disease model construction,protection of endangered species,human organ transplantation and cell differentiation.ESCs combined with gene editing technology to produce large-scale animal models has been widely used in the field of biomedicine.In animal breeding,it has not only improved animal production characteristics and disease resistance,but also produced products with higher value and higher quality,which shows good social value and application prospects.This article briefly reviews the current research status of ESCs,applicationand prospectin animal breeding.
作者
高悦悦
郭帅
顾涛涛
毕延震
方桂杰
华再东
GAO Yue-yue;GUO Shuai;GU Tao-tao;BI Yan-zhen;FANG Gui-jie;HUA Zai-dong(Institute of Animal Husbandry and Veterinary Medicine,Hubei Academy of Agricultural Sciences/Hubei Key Laboratory of Animal Embryonic Engineering and Molecular Breeding,Wuhan 430064,China;College of Bioengineering and Food,Hubei University of Technology,Wuhan 430068,China;Wuhan Newlite Biotechnology Co.,Ltd.,Wuhan 430023,China)
出处
《湖北农业科学》
2021年第S02期50-53,57,共5页
Hubei Agricultural Sciences
基金
湖南省重点领域研发计划(2020WK2030)
中国科学院战略性先导科技专项(XDA24030204)
湖北省农业科技创新中心项目(2022-620-000-001-20)
国家自然科学基金(31772577)
湖北省农科院领军人才(L2018015)
湖南创新型省份建设专项经费(2019RS1068)
重点实验室开放课题(KLAEMB-2021-05)
外国青年人才计划(QN20200127002)
关键词
胚胎干细胞
基因编辑
动物育种
embryonic stem cells
gene editing
animal breeding
