摘要
选取第五周期元素碘,结合多学科的研究方法论对含碘氨基酸类激素在生物体内的合成和分解代谢进行系统性分析。通过解析碘元素本身性质及其各个氧化态之间的转化,探讨碘元素在生物体内的作用机制,揭示自然界对物质代谢的精细调控。这一教学模式探索性地融入无机化学、元素有机化学、分子生物学、生物化学、生物物理学、化学生物学等一系列学科内容,旨在让学生在领悟生命科学内在规律,从而激发其科研及学习热情,并训练学生的类比思维和思辨能力。期对培养21世纪跨学科综合型人才的培养有所助益。
The periodic table,as the incarnation of the periodic trends,has an instructive role in the development of modern chemistry and its relevant disciplines,such as the studies into the in vivo distribution and mechanism of long-period,nonmetal trace elements.This manuscript specifically focuses on one period 5 element,iodine,by systemically analyzing the biosynthesis and degradation of iodine-containing amino acid-derived hormones to explore the mechanism of iodine by combining methodologies from different disciplines.Through analyzing the transformation of different oxidation states and the intrinsic property of iodine as a chemical element,we reveal both the irreplaceable role of iodine in vivo,and the meticulous regulation upon the synthesis and degradation of biomolecules in nature.The combination and integration of many interdisciplinary subjects such as inorganic chemistry,element organic chemistry,coordination chemistry,enzymology,molecular biology,bioorganic chemistry,biophysics and chemical biology are intended to not only impel students to learn the intrinsic rules of biological sciences,but also to train their ability of analogy and critical thinking in order to arouse their enthusiasm towards learning and scientific research.
作者
王志鹏
马新雨
蒋振雄
姜汉杰
王鹏
尹晟
缑允梓
许兵
袁金颖
WANG Zhipeng A;MA Xin-Yu;JIANG Zhen-Xiong;JIANG Han-Jie;WANG Peng;YIN Sheng;GOU Yun-Zi;XU Bing;YUAN Jin-Ying(Department of Chemistry,Tsinghua University,Beijing 100084,China;Department of Chemistry,Texas A&M University,College Station,TX 77843,United States;Department of Biology,Texas A&M University,College Station,TX 77843,United States;Division of Genetics,Department of Medicine,Brigham and Women's Hospital;Department of Biological Chemistry and Molecular Pharmacology,Harvard Medical School,Boston,MA 02115,United States;Burn Surgery,The First Affiliated Hostital,Sun Yat-sen University,Guangzhou 510080,China;Nutrition/Metabolism Laboratory,Department of Surgery,Beth Israel Deaconess Medical Center,Harvard Medical School,Boston,MA 02138,United States;Department of Plant Pathology and Microbiology,Texas A&M University,College Station,TX 77840,United States)
出处
《化学教育（中英文）》
CAS
北大核心
2020年第4期6-13,共8页
Chinese Journal of Chemical Education
关键词
元素周期律
碘元素
甲状腺激素
合成分解代谢
periodic trends
iodine element
thyroid hormone
metabolism and catabolism
