摘要
目的探讨无创机械通气联合重组人脑利钠肽(rhBNP)治疗重症心力衰竭(HF)对患者心功能及血气指标的影响。方法选取2022年1月—2023年12月我院收治的60例重症HF患者为研究对象,应用随机数字表法将其分为对照组与观察组,各30例。对照组采用rhBNP治疗,观察组在此基础上联合无创机械通气。比较两组的临床疗效、心功能、血气指标及不良反应。结果治疗后,观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组心功能、血气指标比较,组间差异无统计学意义(P>0.05);治疗后,观察组心脏指数、左心室射血分数水平均高于对照组,左心室舒张末期内径、左心室收缩末期内径水平均短于对照组,动脉血氧分压为(78.64±5.73)mmHg(1 mmHg=0.133 kPa),血氧饱和度为(70.04±4.87)%,均高于对照组的(70.12±4.67)mmHg、(60.15±4.26)%,动脉血二氧化碳分压为(32.15±2.87)mmHg,低于对照组的(43.69±3.24)mmHg,组间差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论无创机械通气联合rhBNP治疗可有效维持重症HF患者血气指标稳定,改善心脏功能,且较为安全。
Objective To investigate the effect of noninvasive mechanical ventilation combined with recombinant human brain natriuretic peptide(rhBNP)on cardiac function and blood gas indexes in patients with severe heart failure(HF).Methods Sixty patients with severe HF admitted to our hospital from January 2022 to December 2023 were selected as the research objects,and were divided into a control group and an observation group by random number table method,with 30 cases in each group.The control group was treated with rhBNP,and the observation group was treated with noninvasive mechanical ventilation on this basis.The clinical efficacy,cardiac function,blood gas indexes and adverse reactions were compared between the two groups.Results After treatment,the total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no statistically significant differences in cardiac function and blood gas indexes between the two groups(P>0.05).After treatment,the levels of cardiac index and left ventricular ejection fraction in the observation group were higher than those in the control group,and the levels of left ventricular end-diastolic diameter and left ventricular end-systolic diameter were shorter than those in the control group,the arterial oxygen partial pressure was(78.64±5.73)mmHg(1 mmHg=0.133 kPa),and the blood oxygen saturation was(70.04±4.87)%.They were higher than(70.12±4.67)mmHg,(60.15±4.26)%in the control group,and the partial pressure of carbon dioxide in arterial blood was(32.15±2.87)mmHg,lower than(43.69±3.24)mmHg in the control group,the differences between the two groups were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Noninvasive mechanical ventilation combined with rhBNP therapy can effectively maintain the stability of blood gas indexes and improve cardiac function in patients with severe HF,and it is safe.
作者
窦微微
亢凤兵
刘洪雨
杜彩云
DOU Weiwei;KANG Fengbing;LIU Hongyu;DU Caiyun(Department of Critical Care Medicine,Daxing District Hospital of Integrated Traditional Chinese and Western Medicine,Beijing 100076,China;Department of Ultrasound,Daxing District Hospital of Integrated Traditional Chinese and Western Medicine,Beijing 100076,China)
出处
《反射疗法与康复医学》
2024年第8期141-144,共4页
Reflexology And Rehabilitation Medicine
关键词
心力衰竭
重症
无创机械通气
重组人脑利钠肽
心功能
Heart failure
Severe
Noninvasive mechanical ventilation
Recombinant human brain natriuretic peptide
Cardiac function
