摘要
目的分析腹腔镜术后行静脉及腹腔热灌注化疗对结直肠癌患者的影响。方法选取2020年1月—2023年1月国药北方医院收治的74例腹腔镜术后的结直肠癌患者为研究对象,按随机数字表法将其分为对照组和观察组,各37例。对照组术后行静脉化疗,观察组加以腹腔热灌注化疗。对比两组的肿瘤标志物、复发率、生存率、不良反应发生情况。结果观察组术后的癌胚抗原为(5.29±0.50)ng/mL,糖类抗原125为(25.71±2.89)U/mL,糖类抗原199为(26.52±2.57)U/m L,均低于对照组的(8.58±1.29)ng/mL、(32.35±4.76)U/mL、(32.63±3.70)U/mL,组间差异有统计学意义(P<0.05)。两组复发率、生存率、不良反应发生率比较,组间差异无统计学意义(P>0.05)。结论腹腔镜术后行静脉及腹腔热灌注化疗能够杀灭结直肠癌患者体内的癌细胞,减少复发,提高生存率,且无严重不良反应。
Objective To analyze the impact of intravenous and intraperitoneal thermal perfusion chemotherapy after laparoscopic surgery on patients with colorectal cancer.Methods 74 patients with postoperative colorectal cancer treated with laparoscopic surgery at National Pharmaceutical North Hospital from January 2020 to January 2023 were selected as the research objects and randomly divided into a control group and an observation group,with 37 patients in each group,using a random number table method.The control group received intravenous chemotherapy after surgery,while the observation group received intraperitoneal thermal perfusion chemotherapy.Compare tumor markers,recurrence rate,survival rate,and adverse reactions between the two groups.Results The postoperative levels of carcinoembryonic antigen was(5.29±0.50)ng/mL,carbohydrate antigen 125 was(25.71±2.89)U/mL,and carbohydrate antigen 199 was(26.52±2.57)U/mL in the observation group were lower than(8.58±1.29)ng/mL,(32.35±4.76)U/mL,and(32.63±3.70)U/mL in the control group,the differences between groups were statistically significant(P<0.05).There was no statistically significant difference between the two groups in terms of recurrence rate,survival rate,and incidence of adverse reactions(P>0.05).Conclusion Intravenous and intraperitoneal thermal perfusion chemotherapy after laparoscopic surgery can kill cancer cells in patients with colorectal cancer,reduce recurrence,improve survival rate,and have no serious adverse reactions.
作者
牛津
NIU Jin(Department of General Surgery,North Hospital of Sinopod,Baotou Inner Mongolia,014000,China;Department of Burn and Plastic Surgery,Sinopharm North Hospital,Baotou Inner Mongolia,014000,China)
出处
《反射疗法与康复医学》
2024年第7期130-132,共3页
Reflexology And Rehabilitation Medicine
关键词
结直肠癌
化疗
不良反应
复发
肿瘤标志物
Colorectal cancer
Chemotherapy
Adverse reactions
Recurrence
Tumor markers
