摘要
目的探讨卡瑞利珠单抗联合仑伐替尼治疗晚期肝癌患者的效果。方法回顾性分析2020年1月—2023年1月于我院接受治疗的86例晚期肝癌患者的临床资料。依据治疗方案的不同,将接受仑伐替尼治疗的43例患者纳入对照组,将接受卡瑞利珠单抗联合仑伐替尼治疗的43例患者纳入观察组。比较两组治疗有效性、生化指标水平与安全性。结果观察组疾病控制率为72.09%,高于对照组的48.84%,差异有统计学意义(P<0.05)。治疗3个疗程后,观察组甲胎蛋白(AFP)、异常凝血酶原(APT)水平均低于对照组,组间差异有统计学意义(P<0.05)。两组手足综合征、疲乏、皮疹、腹泻、食欲下降、胆红素升高、急性肾损伤、甲状腺功能减退、肝功能异常、血小板减少发生率比较,组间差异无统计学意义(P>0.05)。结论晚期肝癌患者经卡瑞利珠单抗联合仑伐替尼治疗效果显著,可有效改善AFP、APT水平,且具有一定安全性。
Objective To explore the efficacy of camrelizumab combined with lenvatinib in the treatment of advanced liver cancer patients.Methods A retrospective analysis was conducted on the clinical data of 86 patients with advanced liver cancer who received treatment in our hospital from January 2020 to January 2023.According to different treatment plans,the data of 43 patients receiving lenvatinib treatment were divided into a control group,and the data of 43 patients receiving camrelizumab combined with lenvatinib treatment were divided into an observation group.The therapeutic efficacy,biochemical indicators,and safety of the two groups were compared.Results The disease control rate of the observation group was 72.09%,higher than 48.84%of the control group,and the difference was statistically significant(P<0.05).After three courses of treatment,the levels of alpha-fetoprotein(AFP),abnormal prothrombin(APT)in the observation group were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).There was no statistically significant difference in the incidence of hand foot syndrome,fatigue,rash,diarrhea,decreased appetite,elevated bilirubin,acute kidney injury,hypothyroidism,liver dysfunction,and thrombocytopenia between the two groups(P>0.05).Conclusion The combination of camrelizumab and lenvatinib in the treatment of advanced liver cancer patients has a significant effect,can effectively improve AFP and APT levels,and has a certain security.
作者
梁劲波
彭荣
LIANG Jinbo;PENG Rong(Department of Oncology,Yicheng People's Hospital,Yicheng Hubei,441400,China)
出处
《反射疗法与康复医学》
2024年第7期157-159,163,共4页
Reflexology And Rehabilitation Medicine
