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妊娠合并甲减不同孕周干预对妊娠结局的影响

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摘要 目的通过研究不同孕周开始治疗妊娠合并甲减对妊娠结局的影响,证实妊娠早期筛查甲状腺疾病的重要性和必要性,从而建议本地区妇幼保健工作将甲状腺疾病筛查纳入孕妇早期检查项目。方法将需要左旋甲状腺素钠片(L-T4)治疗的甲减孕妇,根据起始筛查、治疗时间分三期:T1期:妊娠早期(孕0~13+6周)、T2期:妊娠中期(孕14~26+6周)、T3期:妊娠晚期(孕27~42周),通过筛查,诊断为临床甲减及需要治疗的亚临床甲减孕妇,立即予L-T4治疗,每周复测FT4、TSH、TPOAb,根据控制目标,调整L-T4剂量,尽早使TSH达标,TSH达标后每四周监测FT4、TSH、TPOAb,有异常随时调整L-T4剂量。结果三期子痫前期、胎盘早剥、胎膜早破等母体并发症的发生率差别无统计学意义(P>0.05),羊水量异常、产后出血三期有统计学意义,T1期明显低于T3期开始治疗组(P<0.05),三期分娩方式差别无统计学意义(P>0.05),三期早产、新生儿窒息、低体重出生儿发生差别无统计学意义(P>0.05)。结论妊娠合并甲减,越早开始治疗,相关并发症发生越少,证实早期筛查甲状腺疾病的重要性和必要性,因此本地区妇幼保健工作将甲状腺疾病筛查纳入孕妇早期免费检查项目有重要意义。
作者 陈娟 赵菊
出处 《实用妇科内分泌电子杂志》 2020年第4期27-28,33,共2页 Electronic Journal of Practical Gynecological Endocrinology
基金 妊娠合并甲减不同孕周干预对妊娠结局的影响(课题编号:WKZD2018014)
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