摘要
目的:探讨非刚性配准前后多期动态对比增强磁共振成像(DCE-MRI)扫描定量分析孤立性肺结节的可重复性研究。方法:使用1.5T磁共振对27例孤立性肺结节患者行DCE-MRI扫描。应用Omnikinetics软件对DCE-MRI图像进行非刚性校准。两位放射科医师测量校准前后DCE-MRI定量参数:容量转移常数(k^trans)、速率常数(kep)、血管外细胞间隙容积比(ve)各两次,两次测量间隔两周。采用组内相关系数(ICC)及Bland-Altman法分析测量者内部和测量者间一致性以及可重复性。结果:同一测量者进行两次测量,配准前k^trans、kep和ve的ICC分别为0.962、0.736和0.708,配准后,ICC分别为0.983、0.962和0.834。配准后较配准前均有所提高。配准前k^trans、kep和ve测量值的可重复性分别为4.8%、33.5%和9.6%,配准后分别为1.6%、13.9%和4.3%。配准后可重复性较配准前好。不同测量者之间,配准前k^trans、kep和ve的ICC分别为0.945、0.760和0.931,配准后,ICC分别为0.988、0.962和0.976。配准后k^trans、kep和ve测量值的可重复性分别为1.8%、13.7%和13.1%较配准前的可重复性分别为3.9%,35.7%和20.1%好。结论:非刚性配准技术可以提高测量孤立性肺结节DCE-MRI定量参数结果的可重复性。
Objective:To investigate the repeatability before and after non-rigid registration in dynamic contrast-enhanced MRI quantitative analysis of solitary pulmonary nodules.Methods:Twenty-seven solitary pulmonary nodules underwent DCE-MRI examination on a 1.5 Tesla MR scanner.OmniKinetics software was applied with non-rigid registration of DCE-MRI.Two radiologists measured DCE-MRI quantitative parameters before and after the registration twice:capacity transfer constant(k^trans),rate constants(kep),extravascular extracellular space volume ratio(ve),measured twice two weeks apart.The Bland-Altman analysis and Intraclass correlation coefficient(ICC)were used to assess the reproducibility of the quantitative parameters of inter-and intra-observer agreement.Result:The same reader measured twice,the value of ICC were 0.962(k^trans),0.736(kep),0.708(ve)before registration,and after were 0.983,0.962,0.834,respectively.After registration quantitative parameters were higher than before.After registration repeatability of k^trans,kep,ve measurement(1.6%,13.9%,4.3%)better than before(4.8%,33.5%,9.6%).Between different readers,the value of ICC were 0.945(k^trans),0.760(kep),0.931(ve)before registration,and after were 0.988,0.962,0.976,after registration quantitative parameters were also higher than before.After registration repeatability of k^trans,kep,ve measurement(1.8%,13.7%,13.1%)better than before(3.9%,35.7%,20.1%),respectively.Conclusion:Non-rigid registration technique can improve the repeatability of the measurement of solitary pulmonary nodule DCE-MRI quantitative parameters.
作者
张明珠
冯峰
夏淦林
陈瑜凤
傅爱燕
施冬辉
ZHANG Mingzhu;FENG Feng;XIA Ganlin;CHEN Yufeng;FU Aiyan;SHI Donghui(Department of Radiology,Nantong Tumor Hospital,Nantong 226361,China)
出处
《CT理论与应用研究（中英文）》
2020年第1期1-10,共10页
Computerized Tomography Theory and Applications
基金
南通市科技局应用研究项目(MS22015107)
南通市卫计委青年基金(WQ2014047).
关键词
孤立性肺结节
磁共振成像
非刚性配准
可重复性
solitary pulmonary nodule
magnetic resonance imaging
non-rigid registration
repeatability
