摘要
目的探讨静息态功能磁共振成像(f MRI)在首诊精神分裂症患者中的应用价值。方法选取2016年1月-2018年9月间收治的42例精神分裂症患者(观察组)和40例志愿者(对照组)作为研究对象,两组均行f MRI检查。比较两组功能连接异常的脑区。结果观察组与对照组对比,精神分裂症患者左侧楔前叶、扣带回、左侧中央前回、双侧中央后回、双侧舌回、右侧颞中回、右侧颞上极、左侧颞横回、双侧顶上小叶、左侧岛叶功能连接异常增强(P<0.05),精神分裂症患者左侧额中回、左侧顶下小叶、双侧额上回、右侧眶下回功能接连异常减弱(P<0.05)。结论静息态f MRI能有效显示首诊精神分裂症患者的多个脑区功能连接异常及其变化。
Objective To explore the application value of resting-state functional magnetic resonance imaging(f MRI)in patients with firstly-diagnosed schizophrenia.Methods A total of 42 patients with schizophrenia(observation group)and 40 volunteers(control group)from January 2016 and September 2018 were selected for the study.f MRI was performed in the two groups.Brain regions with abnormal functional connections were compared between the two groups.Results Compared with control group,the abnormal functional connections of left precuneus,cingulate gyrus,left precentral gyrus,bilateral postcentral gyrus,bilateral gyrus lingualis,right gyrus temporalis medius,right gyrus temporalis superior,left gyri temporales transversi,bilateral superior parietal lobule and left insular lobe of patients with schizophrenia were enhanced in observation group(P<0.05),and the abnormal functional connections of left gyrus frontalis medius,left inferior parietal lobule,bilateral gyrus frontalis superior and right infraorbital gyrus of patients with schizophrenia were weakened(P<0.05).Conclusion f MRI in resting state can effectively show the functional connection abnormalities and changes of multiple brain regions in the first diagnosis of schizophrenia.
作者
阿提坎·台外库里
Attican Offshore Curie(Department of General Psychiatry,First People's Hospital,Xinjiang 844000,China)
出处
《中国CT和MRI杂志》
2020年第1期35-37,共3页
Chinese Journal of CT and MRI
基金
新疆维吾尔自治区自然科学基金资助项目(20141118).
关键词
精神分裂症
首诊患者
静息态功能磁共振成像
Schizophrenia
Firstly-diagnosed Patients
Resting-state Functional Magnetic Resonance Imaging
