摘要
化合物的谱学表征对于物质的研究与开发具有重要的意义。太赫兹波是指位于微波和远红外波之间频段的电磁波。化合物分子内部的振动-转动、许多生物大分子的低频振动和分子间弱作用的振动频率恰好处于太赫兹频段,因此太赫兹光谱与成像技术是研究化合物表征和分子作用机制的有效手段。将太赫兹光谱技术用于M-EDTA络合物、不同价态铁的络合物的表征,结果表明太赫兹光谱可以作为该类化合物的有效表征方法。环糊精包合物和瓜环包合物在分子识别和新型药物开发中受到关注。将太赫兹光谱技术用于环糊精包合物和瓜环包合物的表征研究,结果表明根据太赫兹光谱特征可以辨别它们的键合方式,为环糊精包合物和瓜环包合物的研究与开发提供了一种新的方法。太赫兹光谱技术结合化学计量学方法还被用于氨基酸三元混合物和糖同分异构三元混合物的定量分析。
Characterization of compounds by spectral methods is important to studies and development of materials.Terahertz waves lie between the microwave and far infrared waves.The frequencies of intramolecular vibration-rotation and low frequency intermolecular vibration and weak interactions of many bio-molecules fall into the terahertz range.Therefore,terahertz spectroscopy and terahertz imaging can be useful tools for studying compounds characterization and chemical mechanism.In the present work,terahertz spectroscopy has been applied to characterizing M-EDTA complexes and Fe(Ⅱ)and Fe(Ⅲ)complexes and with the same ligands.Results show that the terahertz spectroscopy can be an effective means for characterizing these compounds.Cyclodextrin inclusion compound and cucurbit inclusion complex used for molecular recognition and novel drug development caused more attention in recent years.We used terahertz spectroscopy to characterize cyclodextrin inclusion compound and cucurbit inclusion complex.Results show that the terahertz spectroscopy can give information about the mode of bonding,and can be used as a novel approach for scientific research and development.Terahertz spectroscopy combined with chemometrics was also used for quantitative analyses of ternary amino acids mixtures and ternary saccharides mixtures.
作者
张卓勇
ZHANG Zhuo-yong(Department of Chemistry,Capital Normal University,Beijing 100048,China)
出处
《光谱学与光谱分析》
SCIE
EI
CAS
CSCD
北大核心
2020年第S01期299-300,共2页
Spectroscopy and Spectral Analysis
关键词
太赫兹光谱
光谱表征
M-EDTA络合物
环糊精
瓜环
Terahertz spectroscopy
Spectral characterization
M-EDTA complex
Cyclodextrin
Cucurbit
