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加味防己黄芪汤治疗原发性肾病综合征临床观察 被引量:6

The Effect of Modified Fangji Huangqi Decoction in the Treatment of Primary Nephrotic Syndrome
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摘要 目的探讨加味防己黄芪汤在原发性肾病综合征患者中的应用效果。方法选择2017年5月—2019年5月收治的原发性肾病综合征患者94例,以随机数字表法进行分组,其中对照组与研究组各纳入47例。对照组采取常规激素、降脂、抗凝、利尿等西药治疗,研究组在此基础上应用加味防己黄芪汤治疗。对比2组临床疗效,以及治疗前后肾功能指标与微炎症指标的变化。结果研究组治疗的总有效率为89.36%,高于对照组68.09%(P<0.05)。治疗后研究组24 h尿蛋白定量低于对照组(P<0.01),血浆白蛋白高于对照组(P<0.01),2组血肌酐对比差异无统计学意义(P>0.05)。治疗后研究组IL-8、hs-CRP指标均低于对照组(P<0.01)。结论加味防己黄芪汤能够提高原发性肾病综合征患者的临床疗效,改善其肾功能与机体微炎症状态,值得临床推广。 Objective To explore the effect of modified Fangji Huangqi decoction in patients with primary nephrotic syndrome.Methods 94 patients with primary nephrotic syndrome admitted to our hospital from May 2017 to may 2019 were randomly divided into control group and study group,with 47 cases in each group.The control group was treated with conventional hormone,lipid-lowering,anticoagulation,diuresis and other Western medicine,and the study group was treated with modified Fangji Huangqi decoction on this basis.The clinical effects of the two groups were compared,and the changes of renal function indexes and micro inflammation indexes before and after treatment were compared.Results The total effective rate of the study group was 89.36%which was higher than that of the control group(68.09%)(P<0.05).After treatment,the 24-hour urine protein quantity of the study group was lower than that of the control group(P<0.01),and the albumin of the study group was higher than that of the control group(P<0.01).There was no significant difference in serum creatinine between the two groups(P>0.05).The levels of IL-8 and hs CRP in the study group were lower than those in the control group(P<0.01).Conclusion Modified Fangji Huangqi decoction can improve the clinical effect of primary nephrotic syndrome,improve its renal function and micro inflammatory state,which is worthy of clinical promotion.
作者 孙宏 杨曦 SUN Hong;YANG Xi(Department of Nephrology,Shifang Hospital of Traditional Chinese Medicine,Sichuan Province,Shifang 618400,China)
出处 《光明中医》 2020年第9期1340-1343,共4页 GUANGMING JOURNAL OF CHINESE MEDICINE
关键词 中西医结合疗法 加味防己黄芪汤 原发性肾病综合征 therapy of integrated medicine modified Fangji Huangqi decoction primary nephrotic syndrome
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