摘要
目的:探讨洛铂用于结直肠癌术中腹腔灌注化疗的药代动力学特点。方法:选择2020年3月至2022年1月于我院接受腹腔镜手术且术中应用洛铂(浓度120 mg/L)进行腹腔灌注化疗的80例结直肠癌患者为研究对象,分别于灌注后即刻、0.5 h、1 h、2 h、3 h、4 h、6 h、10 h、24 h采集患者腹腔引流液和外周静脉血,采用高效液相色谱串联质谱联用技术(LC-MS)检测其中洛铂浓度。结果:灌注后即刻、0.5 h、1 h、2 h、3 h、4 h、6 h、10 h、24 h腹腔引流液洛铂平均药物浓度及药物最大浓度均明显高于血浆中药物浓度,腹腔引流液中洛铂消除半衰期明显长于血浆中半衰期,0~24 h药-时曲线下面积(AUC)明显大于血浆中,P<0.001。结论:洛铂用于结直肠癌术中腹腔灌注化疗,腹腔中可维持较长时间高药物浓度,血液吸收少,安全性高。
Objective To explore the pharmacokinetics characteristics of lobaplatin for intraoperatively peritoneal perfusion chemotherapy of colorectal cancer.Methods Enrolled 80patients with colorectal cancer to be subject to laparoscopic surgery and intraoperatively using lobaplatin(concentration,120mg/L)for peritoneal perfusion chemotherapy in authors'hospital(2020-03-2022-01)into this research:at once after perfusion and at 0.5,1,2,3,4,6,10and 24(hrs)sampled their peritoneal drainage fluid and peripheral blood,in which lobaplatin concentration was detected by using LC-MS technique.Results At above every time-points the average concentration and max.concentration of peritoneal drainage fluid were significantly higher than the concentration in plasma;the half-life of lobaplatin removed in the fluid was significantly longer than one in plasma,within 0-24hrs AUC(drug-time)was significantly larger than one in plasma(P<0.001).Conclusion Lobaplatin for peritoneal perfusion chemotherapy intraoperatively on colorectal cancer patients can make high peritoneal drug-concentration maintaining for longer time,blood absorption is less,and safety is high.
作者
刘永青
肖开
吴通
LIU Yong-qing;XIAO Kai;WU Tong(Pharmacy Division,Zhengzhou City's Third People's Hospital,Zhengzhou,Henan 450000)
出处
《中国肛肠病杂志》
2023年第2期8-10,共3页
Chinese Journal of Coloproctology
关键词
结直肠癌
洛铂
腹腔灌注化疗
药代动力学
分析
Colorectal cancer
Lobaplatin
Peritoneal perfusion chemotherapy
Pharmacokinetics
Analysis
