摘要
目的:探讨他汀药物不同剂量对急性心肌梗死(AMI)疗效的影响差异。方法:共选取我院100例AMI患者,均于发病12h内入院行PCI术治疗,随机数表法将其分为小剂量组和大剂量组,两组各50例,常规内科治疗基础上,小剂量组口服阿托伐他汀20mg/d,大剂量组口服阿托伐他汀40mg/d,均持续治疗4w。观察两组血脂、心功能、炎症因子水平以及心血管不良事件(MACE)情况。结果:大剂量组治疗4w后TG、TC、LDL-C、LVEDD、LVESD、hs-CRP、IL-6较小剂量组下降更为显著,HDL-C、LVEF升高明显;大剂量组MACE发生率12.00%高于小剂量组8.00%,但二者相较差异并不显著。结论:他汀药物治疗AMI的疗效存在剂量效应,给予大剂量40mg/d治疗调脂、改善心功能和抑制炎性反应效果更佳,可作为临床治疗的参考方案。
Objective To investigate the effect of different doses of statins on the efficacy of acute myocardial infarction(AMI).Methods A total of 100 patients with AMI in our hospital were treated with PCI within 12 hours of onset.They were randomly divided into low-dose group and high-dose group,50 cases in each group.On the basis of routine medical treatment,the lowdose group took atorvastatin 20 mg/d orally,and the high-dose group took atorvastatin 40 mg/d orally,all of which lasted for 4 weeks.The levels of blood lipids,cardiac function,inflammatory factors and cardiovascular adverse events(MACE)in the two groups were observed.Results After 4 weeks of treatment,TG,TC,LDL-C,LVEDD,LVESD,hs-CRP,IL-6 decreased more significantly in the high dose group,while HDL-C and LVEF increased significantly in the low dose group.The incidence of MACE was 12.00%in high dose group and 8.00%in low dose group,but there was no significant difference between them.Conclusion Statin has a dose effect in the treatment of AMI.High dose of 40mg/d is more effective in regulating lipid,improving cardiac function and inhibiting inflammatory reaction.It can be used as a reference for clinical treatment.
作者
金艺
韩丹
徐幸
朱佩敏
Jin Yi;Han Dan;Xu Xing;Zhu Pei-min(Emergency Care Unit,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《湖南师范大学学报（医学版）》
2019年第6期67-69,共3页
Journal of Hunan Normal University(Medical Sciences)
