摘要
目的探讨血清胱抑素C(cystatinC,CysC)、β_(2)-微球蛋白(β_(2)-microglobulin,β_(2)-MG)、血肌酐(serum creatinine,SCr)、尿素氮(urea nitrogen,BUN)水平检测在诊断产前子痫前期患者肾损伤中的价值.方法选择40例产前子痫前期患者(子痫前期组)和50例正常晚孕妇女(正常晚孕组),检测其血清CysC、β_(2)-MG、SCr和BUN水平,利用受试者工作特征(receiver operating characteristic,ROC)曲线分析CysC、β_(2)-MG、SCr和BUN在诊断产前子痫前期肾损伤中的价值.结果两组间年龄、孕周比较差异均无统计学意义(P均>0.05).子痫前期组CysC、β_(2)-MG、SCr、BUN水平均明显高于正常晚孕组,且差异均有统计学意义(P均<0.01),四个指标间两两均呈正相关(P均<0.05).CysC、β_(2)-MG、SCr、BUN的ROC曲线下面积分别为0.940、0.801、0.699、0.691.结论在判断产前重度子痫前期肾功能损伤检测指标中,CysC、β_(2)-MG是更为敏感的指标,尤以CysC敏感性最高.
Objective To explore the application value of cystatin C(CysC),β_(2)--microglobulin(β_(2)-MC),serum creatinine(SCr)and urea nitrogen(BUN)detecting in diagnosis of pre-eclampsia patients with renal injury.Methods 40 pre-eclampsia patients(pre-eclampsia group)and 50 normal late pregnancy women(normal late pregnancy group)were collected.CysC,β_(2)-MG,SCr and BUN levels in serum were detected.The values of CysC,β_(2)-MG,BUN and SCr to diagnose pre-eclampsia patients with renal injury were analyzed using receiver operating characteristic(ROC)curve.Results There were no statistical significance in the differences of age and gestational weeks between the two groups(Pall>0.05).The levels of CysC,β_(2)-MG,SCr and BUN in preeclampsia group were significantly higher than those in normal late pregnancy group and the differences all had statistical significance(Pall<0.01).There were positive correlation between each two indexes(Pall<0.05).ROC curve analysis showed that the area under curve of CysC,β_(2)-MG,SCr and BUN were 0.940,0.801,0.699 and 0.691 respectively.Conclusion Serum CysC and β_(2)-MG are the sensitive markers in diagnosis of pre eclampsia patients with renal injury.While CysC is more sensitive than β_(2)-MC.
作者
袁恩武
刘军杰
杜红梅
孟祥颖
YUAN En-wu;LIU Jun-jie;DU Hong-mei(Department of Clinical Laboratory,Third Affiliated Hospitalof Zhengzhou University,Zhengzhou 450052,China)
出处
《实用检验医师杂志》
2011年第3期156-158,共3页
Chinese Journal of Clinical Pathologist
