摘要
泌尿系结石是一种泌尿系统的常见性、易复发性疾病,其病因及发病机制尚不明确.肾脏是对氧化还原失衡特别敏感的器官,过量生成的活性氧簇和氧化应激参与了肾小管上皮细胞损伤、炎症和肾结石的病理形成.肾脏Randall斑的存在证实了氧化应激可诱导肾脏损伤、结石生成.流行病学研究发现,肾结石与全身代谢性疾病密切相关,故可将肾结石视为一种慢性代谢性疾病,而氧化应激可能是它们共同的病理生理学基础.本文旨在阐释氧化应激在肾结石形成中的作用机制,总结归纳氧化应激作为肾结石治疗靶点的潜力,为泌尿系结石的防治提供新思路.
Urolithiasis is a common recurrent disease of the urinary system,and its etiology and pathogenesis remain unclear.The kidney is particularly sensitive to redox imbalance.Excessive reactive oxygen species and oxidative stress are involved in injury to renal tubular epithelial cells,inflammation and the pathological formation of renal calculi.The presence of renal Randall patches has confirmed that oxidative stress induces renal injury and stone formation.Epidemiological studies have shown that renal calculi are closely associated with systemic metabolic diseases and therefore can be regarded as a chronic metabolic disease.Furthermore,oxidative stress may be a pathophysiological basis shared by these diseases.This paper aims to explain the mechanisms of oxidative stress in the formation of renal calculi;summarize the potential of oxidative stress as a therapeutic target for renal calculi;and provide new ideas for the prevention and treatment of urinary calculi.
作者
周建甫
王树声
向松涛
Zhou Jianfu;Wang Shusheng;Xiang Songtao(Department of Urology,Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Guangzhou,Guangdong,510370,China)
出处
《泌尿外科杂志（电子版）》
2021年第3期90-93,共4页
Journal of Urology for Clinicians(Electronic Version)
基金
广东省自然科学基金博士启动纵向协同项目(No.2017A030310501)
广东省中医药局重点科研项目(No.20173009)
广州中医药大学“高水平大学建设”青年项目(No.A1-AFD01817Z11103)
关键词
泌尿系结石
肾结石
氧化应激
活性氧
代谢性疾病
疾病防治
Urinary calculi
Renal calculus
Oxidative stress
Reactive oxygen species
Metabolic diseases
Disease control
