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Ascitic Fluid Analysis in the Differential Diagnosis of Ascites:Focus on Cirrhotic Ascites 被引量:16

Ascitic Fluid Analysis in the Differential Diagnosis of Ascites:Focus on Cirrhotic Ascites
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摘要 Ascites is the pathologic accumulation of fluid within the peritoneal cavity.Because many diseases can cause ascites,in particular cirrhosis,samples of ascitic fluid are commonly analyzed in order to develop a differential diagnosis.The concept of transudate versus exudate,as determined by total protein measurements,is outdated and the use of serumascites albumin gradient as an indicator of portal hypertension is more accurate.Lactate dehydrogenase (LDH),vascular endothelial growth factor (VEGF),and other tumor markers can be helpful in distinguishing between malignant and benign conditions.Glucose and adenosine deaminase levels may support a diagnosis of tuberculous disease,and amylase level may indicate a diagnosis of pancreatitis.Given the specificity and sensitivity of laboratory results,accurate diagnosis should be based on both laboratory data and clinical iudgment. Ascites is the pathologic accumulation of fluid within the peritoneal cavity.Because many diseases can cause ascites,in particular cirrhosis,samples of ascitic fluid are commonly analyzed in order to develop a differential diagnosis.The concept of transudate versus exudate,as determined by total protein measurements,is outdated and the use of serumascites albumin gradient as an indicator of portal hypertension is more accurate.Lactate dehydrogenase (LDH),vascular endothelial growth factor (VEGF),and other tumor markers can be helpful in distinguishing between malignant and benign conditions.Glucose and adenosine deaminase levels may support a diagnosis of tuberculous disease,and amylase level may indicate a diagnosis of pancreatitis.Given the specificity and sensitivity of laboratory results,accurate diagnosis should be based on both laboratory data and clinical iudgment.
出处 《Journal of Clinical and Translational Hepatology》 SCIE 2014年第1期58-64,共7页 临床与转化肝病杂志(英文版)
基金 This project was sponsored in part by grants from the National Natural Science Foundation of China(#81072044) the Guangdong Natural Science Foundation(#S2011010004653)
关键词 Ascitic fluid analysis Differential diagnosis ASCITES CIRRHOSIS Ascitic fluid analysis Differential diagnosis Ascites Cirrhosis
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