摘要
Necroptosis is a new cell death mode which is regulated by precision regulation in recent years,it is initiated when apoptosis is inhibited,and is mediated by receptor ligand and characterized by death-like structure.Among the many factors involved in the process of Necroptosis,RIP1 and RIP3 are essential signaltransduction proteins,and MLKL is the key downstream factor,which mediates down-cascade reaction.Necroptosis plays an important role in the physiological development of inflammation,oxidative stress,tumor proliferation and other diseases.In recent years,with the increasing incidence of various cardiovascular diseases,the expression and regulation of programmed necrosis in cardiovascular diseases has become a hot topic.The role of Necroptosis in the development of CHD is briefly summarized in this paper.
基金
Science and technology in Anhui province(No.1804h08020246)
NSFC(No.817770297)
