摘要
Objective:To study the effects of Schisandra B on neurotransmitter content,inflammation and oxidative stress in the hippocampus of depression model rats.Methods:A total of 30 male SD rats were randomly divided into the control group,the model group,and the Schisandra B group.The latter two groups established depression model according to chronic mild unpredictable stress.The Schisandrin B group was given Schisandrin B gavage for 6 weeks.The differences in depressive behavior and hippocampal neurotransmitter,inflammatory index,oxidative stress index were compared among the three groups.Results:Compared with the control group,the sugar preference score was significantly lower;the immobility time was significantly prolonged;the contents of 5-hydroxytryptamine(5-HT),norepinephrine(NE),dopamine(DA),superoxide dismutase(SOD),glutathione peroxidase(GPx)in hippocampus were significantly decreased;the contents of malondialdehyde(MDA),the expression of nuclear factor-kappa B(NF-κB),interleukin-1beta(IL-1β)and tumor necrosis factor-α(TNF-α)in hippocampus were significantly increased in the model group(P<0.05).Compared with the model group,the sugar preference score was significantly increased;immobility time significantly shortened;the contents of 5-HT,NE,DA,SOD and GPx in hippocampus were significantly increased;the content of MDA and the expression of NF-κB,IL-1βand TNF-αin hippocampus were significantly decreased in ketamine group(P<0.05).Conclusion:Low dose of Schisandra B can improve depressive behavior,increase monoamine neurotransmitter secretion,and inhibit inflammation and oxidative stress in depression model rats.
