摘要
目的探究低剂量阿司匹林辅助治疗对妊娠期高血压的效果.方法选取2020年8月—2021年8月我院收治的84例妊娠期高血压患者为研究对象,按随机数字表法分为两组,每组42例.对照组采用拉贝洛尔治疗,观察组在此基础上采用低剂量阿司匹林治疗,均持续用药至分娩前.比较两组患者的临床疗效、血压水平、血管内皮功能、妊娠结局及不良反应发生情况.结果观察组的治疗总有效率为95.24%,高于对照组的80.95%,差异有统计学意义(P<0.05).治疗2周后,观察组的舒张压、收缩压、平均动脉压均低于对照组,组间差异有统计学意义(P<0.05).治疗2周后,观察组的血清内皮素水平低于对照组,一氧化氮水平高于对照组,组间差异有统计学意义(P<0.05).观察组的不良妊娠结局发生率为4.76%,低于对照组的19.05%,差异有统计学意义(P<0.05).两组的不良反应发生率比较,差异无统计学意义(P>0.05).结论低剂量阿司匹林辅助治疗妊娠期高血压的效果更好,能有效降低患者血压水平,改善其血管内皮功能及妊娠结局,安全可靠.
Objective To investigate the effect of low-dose aspirin adjuvant therapy on gestational hypertension.Methods 84 patients with gestational hypertension admitted to the hospital from August 2020 to August 2021 were selected as the research objects and were divided into two groups according to random number table method,with 42 cases in each group.The control group was treated with labetalol,and the observation group was treated with low-dose aspirin on this basis.Both groups continued the medication until delivery.The clinical efficacy,blood pressure levels,vascular endothelial function,pregnancy outcome and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 95.24%,higher than 80.95%of the control group,the difference was statistically significant(P<0.05).After 2 weeks of treatment,the diastolic blood pressure,systolic blood pressure and mean arterial pressure in the observation group were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).After 2 weeks of treatment,the serum endothelin level in the observation group was lower than that in the control group,and the nitric oxide level was higher than that in the control group,the differences between the groups were statistically significant(P<0.05).The incidence of adverse pregnancy outcome in the observation group was 4.76%,lower than 19.05%in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Low-Dose aspirin adjuvant treatment of gestational hypertension is more effective,can effectively reduce the blood pressure of patients,improve the vascular endothelial function and pregnancy outcome,safe and reliable.
作者
彭红
姜琦
PENG Hong;JIANG Qi(1st Department of Obstetrics,Maternal and Child Health Hospital,Mudan District,Heze City,Heze Shandong,274000,China)
出处
《反射疗法与康复医学》
2023年第8期131-133,141,共4页
Reflexology And Rehabilitation Medicine
关键词
妊娠期高血压
拉贝洛尔
阿司匹林
血压水平
血管内皮功能
Gestational hypertension
Labetalol
Aspirin
Blood pressure level
Vascular endothelial function
