摘要
目的探讨大株红景天注射液联合尼可地尔在冠心病不稳定型心绞痛(UAP)患者中的应用价值.方法选择2020年1月—2021年12月本院收治的冠心病UAP患者98例,按随机数字表法分为两组.对照组(n=49)采用尼可地尔治疗,观察组(n=49)在此基础上采用大株红景天注射液治疗,两组均治疗14 d.对比分析两组患者的内皮功能、血清丙二醛(MDA)水平、超氧化物歧化酶(SOD)水平、血液流变学指标、临床疗效及不良反应发生情况.结果治疗后,观察组的内皮素-1、血栓素B2、MDA水平分别为(57.31±5.20)ng/L、(80.47±9.21)pg/mL、(6.28±0.59)nmol/mL,均低于对照组的(63.95±6.40)ng/L、(96.03±11.85)pg/mL、(7.63±1.04)nmol/mL,一氧化氮、SOD水平分别为(35.39±3.45)μmol/L、(152.09±8.73)U/mL,均高于对照组的(31.41±3.26)μmol/L、(141.96±11.37)U/mL,组间差异有统计学意义(P<0.05).治疗后,观察组的纤维蛋白原、红细胞沉降率、全血黏度、红细胞比容、血浆黏度水平分别为(2.84±0.36)g/L、(16.37±4.91)mm/h、(4.50±0.37)mPa/s、(38.16±3.20)%、(1.63±0.14)mPa/s,均低于对照组的(3.67±0.59)g/L、(24.89±4.65)mm/h、(4.91±0.42)mPa/s、(42.18±3.54)%、(1.97±0.12)mPa/s,组间差异有统计学意义(P<0.05).观察组的治疗总有效率为95.92%,高于对照组的79.59%,差异有统计学意义(P<0.05).两组的不良反应发生率比较,差异无统计学意义(P>0.05).结论大株红景天注射液联合尼可地尔能改善冠心病UAP患者的内皮功能,调节血清MDA、SOD水平,降低FIB、ESR、Hct等血液流变学指标水平,且安全性较高.
Objective To investigate the application value of Rhodiola grandiflora injection combined with nicorandil in patients with unstable angina pectoris(UAP)of coronary heart disease.Methods 98 patients with UAP of coronary heart disease admitted to the hospital from January 2020 to December 2021 were selected and were divided into two groups according to random number table method.The control group(n=49)was treated with nicorandil,and the observation group(n=49)was treated with Rhodiola grandiflora injection on this basis.Both groups were treated for 14 days.The endothelial function,serum malondialdehyde(MDA)level,superoxide dismutase(SOD)level,hemorheology indexes,clinical efficacy and occurrence of adverse reactions were compared between the two groups.Results After treatment,the levels of endothelin-1,thromboxin-B2 and MDA in the observation group were(57.31±5.20)ng/L,(80.47±9.21)pg/mL and(6.28±0.59)nmol/mL,respectively,lower than(63.95±6.40)ng/L,(96.03±11.85)pg/mL,(7.63±1.04)nmol/mL in the control group,while the nitric oxide and SOD levels were(35.39±3.45)μmol/L and(152.09±8.73)U/mL,respectively,higher than(31.41±3.26)μmol/L and(141.96±11.37)U/mL in the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,the levels of fibrinogen,erythrocyte sedimentation rate,whole blood viscosity,hematocrit and plasma viscosity in the observation group were(2.84±0.36)g/L,(16.37±4.91)mm/h,(4.50±0.37)mPa/s,(38.16±3.20)%,(1.63±0.14)mPa/s,respectively,lower than(3.67±0.59)g/L,(24.89±4.65)mm/h,(4.91±0.42)mPa/s,(42.18±3.54)%,(1.97±0.12)mPa/s in the control group,and the differences between the groups were statistically significant(P<0.05).The total effective rate of the observation group was 95.92%,which was higher than 79.59%of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Rhodiola grandiflora injection combined with nicorandil can improve endothelial function,regulate serum MDA and SOD levels,reduce FIB,ESR,Hct and other hemorheological index levels in patients with coronary heart disease with UAP,with high safety.
作者
曹丽娟
刘旭辉
周耀
朱源生
CAO Lijuan;LIU Xuhui;ZHOU Yao;ZHU Yuansheng(Department of Cardiovascular Medicine,Huai'an Second People's Hospital,Huai'an Jiangsu,223001,China)
出处
《反射疗法与康复医学》
2023年第5期40-43,共4页
Reflexology And Rehabilitation Medicine
关键词
冠心病
不稳定型心绞痛
大株红景天注射液
尼可地尔
内皮功能
血液流变学
Coronary heart disease
Unstable angina pectoris
Rhodiola grandiflora injection
Nicorandil
Endothelial function
Hemorheology
