摘要
目的探讨氨磺必利对精神分裂症患者阳性与阴性症状量表(PANSS)评分及生活质量的影响.方法选取2020年2月—2022年1月该院收治的精神分裂症患者84例,按随机抽样法分为对照组42例与观察组42例.对照组采用利培酮治疗,观察组采用氨磺必利治疗,持续用药2个月.比较两组临床疗效、PANSS、精神分裂症患者生活质量量表(SQLS)、锥体外系副反应量表(RSESE)、副反应量表(TESS)评分.结果治疗2个月后,观察组阴性症状评分(7.96±2.21)分、一般精神病理评分(10.87±3.61)分、SQLS评分(20.45±4.08)分、RSESE评分(14.64±1.97)分、TESS评分(20.86±3.45)分,均低于对照组的(12.18±3.40)分、(15.53±4.25)分、(25.64±5.36)分、(17.52±2.16)分、(35.59±4.22)分,组间差异有统计学意义(P<0.05);两组临床总有效率、治疗2个月后阳性症状评分比较,组间差异无统计学意义(P>0.05).结论氨磺必利治疗精神分裂症能取得与利培酮相近的临床效果,并能够进一步改善阴性症状,进而促进患者生活质量提升,且安全性更高.
Objective To investigate the effect of amisulpride on positive and negative symptom scale(PANSS)score and quality of life in patients with schizophrenia.Methods A total of 84 patients with schizophrenia who were admitted to the hospital from February 2020 to Janaury 2022 were selected and divided into a control group of 42 cases and an observation group of 42 cases according to random sampling method.The control group was treated with risperidone,and the observation group was treated with amisulpride,with both interventions for 2 months.The clinical efficacy,PANSS,schizophrenia quality of life scale(SQLS),rating scale for extrapyramidal side effects(RSESE),treatment emergent symptom scale(TESS)scores were compared between the two groups.Results After 2 months of treatment,the negative symptoms score(7.96±2.21)points,general psychopathology score(10.87±3.61)points,SQLS score(20.45±4.08)points,RSESE score(14.64±1.97)points,TESS score(20.86±3.45)points in the observation group were lower than(12.18±3.40)points,(15.53±4.25)points,(25.64±5.36)points,(17.52±2.16)points,(35.59±4.22)points in the control group,and the differences between the groups were statistically significant(P<0.05);there were no statistically significant differences in the clinical total effective rate and positive symptom score after 2 months of treatment(P>0.05).Conclusion Amisulpride in the treatment of schizophrenia can achieve similar clinical effects as risperidone,and can further improve negative symptoms,thereby improving the quality of life of patients,and with higher safety.
作者
崔晓飞
CUI Xiaofei(Department of Psychiatry,Zibo Mental Health Center,Zibo Shandong,255000,China)
出处
《反射疗法与康复医学》
2022年第11期75-77,共3页
Reflexology And Rehabilitation Medicine
