摘要
目的探讨重症脑出血患者在营养支持治疗中采用丙氨酰-谷氨酰胺干预的效果及其对免疫功能的影响.方法选取本院2017年1月—2021年12月收治的重症脑出血患者80例,根据营养支持方案不同分为采用常规营养支持的对照组(n=35)与联合丙氨酰-谷氨酰胺干预的观察组(n=45).比较两组的机体营养状态,机体免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)及肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6).结果治疗后,观察组的血清前白蛋白、白蛋白水平均高于对照组,组间差异有统计学意义(P<0.05).治疗后,观察组的IgA、IgG、IgM水平均高于对照组,组间差异有统计学意义(P<0.05).治疗后,观察组的TNF-α、IL-6水平均低于对照组,组间差异有统计学意义(P<0.05).结论重症脑出血患者采用丙氨酰-谷氨酰胺进行营养支持干预能改善机体营养状态与免疫功能,减轻炎症反应,有利于改善患者预后.
Objective To investigate the effect of alanyl-glutamine intervention in nutritional support therapy for patients with severe cerebral hemorrhage and its effect on immune function.Methods A total of 80 patients with severe cerebral hemorrhage admitted to our hospital from January 2017 to December 2021 were selected and were divided into a control group(n=35)with conventional nutritional support and an observation group(n=45)with combined alanyl-glutamine intervention on the basis of the control group according to different nutritional support programs.The nutritional status,immunoglobu-lin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM)and tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)were compared between the two groups.Results After treatment,the serum prealbumin and albumin levels in the observation group were higher than those in the control group,the differences between the groups were statistically significant(P<0.05).After treatment,the levels of IgA,IgG and IgM in the observation group were higher than those in the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,the levels of TNF-αand IL-6 in the observation group were lower than those in the control group,and the differences between the groups were statistically signifi-cant(P<0.05).Conclusion Nutritional intervention with alanyl-glutamine in patients with severe cerebral hemorrhage can improve nutritional status and immune function,reduce inflammatory response,and improve the prognosis of patients.
作者
高吉民
孙妍
GAO Jimin;SUN Yan(Department of Critical Care Medicine,Huaian Medical District,General Hospital of the Eastern Theater Command,Huaian Jiangsu,223001,China;Department of Neurology,Huaian Medical District,General Hospital of the Eastern Theater Command,Huaian Jiangsu,223001,China)
出处
《反射疗法与康复医学》
2022年第8期134-137,共4页
Reflexology And Rehabilitation Medicine
关键词
重症脑出血
丙氨酰-谷氨酰胺
营养支持
免疫功能
炎症反应
Severe cerebral hemorrhage
Alanyl glutamine
Nutritional support
Immune function
The inflammatory response
