摘要
目的探究银杏酮酯滴丸联合替格瑞洛对冠心病心绞痛患者心绞痛发作情况及炎症反应的影响.方法选择本院2020年9月—2021年9月收治的104例冠心病心绞痛患者为研究对象,按照随机数字表法分为对照组和观察组,每组52例.对照组口服替格瑞洛,观察组在对照组基础上加用银杏酮酯滴丸,均持续治疗1个月.比较两组治疗效果、治疗前后心绞痛发作情况、炎症反应及不良反应.结果观察组治疗总有效率为94.23%,高于对照组的78.85%,差异有统计学意义(P<0.05).治疗前,两组心绞痛发作情况、炎症反应比较,组间差异无统计学意义(P>0.05);治疗后,观察组心绞痛发作频率低于对照组,心绞痛持续时间短于对照组,C反应蛋白、白细胞介素-6、白细胞介素-18、肿瘤坏死因子-α水平均低于对照组,组间差异有统计学意义(P<0.05).两组不良反应发生率比较,差异无统计学意义(P>0.05).结论银杏酮酯滴丸联合替格瑞洛治疗冠心病心绞痛的临床效果确切,能够降低心绞痛发作频率,缩短心绞痛发作时间,减轻炎症反应,且安全性高.
Objective To explore the effect of Yinxing Tongzhi dropping pills combined with ticagrelor on angina attack and inflammatory response in patients with coronary heart disease and angina.Methods A total of 104 patients with coronary heart disease and angina who were admitted to our hospital from September 2020 to September 2021 were selected as the research objects,and divided into a control group and an observation group according to the random number table method,with 52 cases in each group.The control group was given ticagrelor orally,and the observation group was given Yinxing Tongzhi dropping pills on the basis of the control group,and the treatment continued for 1 month.The therapeutic effect,angina attack and inflammatory reaction before and after treatment and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 94.23%,which was higher than 78.85%of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in angina attack and inflammatory reaction between the two groups(P>0.05);after treatment,the frequency of angina attack in the observation group was lower than that in the control group,and the duration of angina was shorter than that in the control group,the levels of C-reactive protein,interleukin-6,interleukin-18 and tumor necrosis factor-αwere lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The clinical effect of Yinxing Tongzhi dropping pills combined with ticagrelor in the treatment of coronary heart disease angina is definite,which can reduce the frequency of angina attack,shorten the time of angina,reduce the inflammatory response,and has high safety.
作者
王军民
张文敏
WANG Junmin;ZHANG Wenmin(Department of Cardiovascular Medicine,Weihaiwei People's Hospital,Weihai Shandong,264200,China)
出处
《反射疗法与康复医学》
2022年第2期66-69,共4页
Reflexology And Rehabilitation Medicine
关键词
冠心病心绞痛
银杏酮酯滴丸
替格瑞洛
心绞痛发作情况
炎症反应
Coronary heart disease angina
Yinxing Tongzhi dropping pills
Ticagrelor
Angina attack
Inflammatory response
