摘要
目的分析常规药物联合低频重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)治疗精神分裂症顽固性幻听患者的临床效果.方法将该院于2017年5月—2020年5月收治的80例精神分裂症顽固性幻听患者纳入研究,采用随机数字表法分为两组,每组40例.对照组采用常规药物联合rTMS伪刺激治疗,研究组采用常规药物联合rTMS治疗.对比两组治疗前、治疗4、8、16周的简明精神病评定量表(brief psychiatric rating scale,BPRS)、临床疗效总评量表(clinical global impression,CGI)及听幻觉评分量表(auditory hallucinations rating scale,AHRS)评分,并对比两组治疗前、治疗16周的副反应量表(treatment emergent symptom scale,TESS)评分.结果治疗4、8、16周,研究组的BPRS、CGI及AHRS评分均低于对照组,组间差异有统计学意义(P<0.05);治疗16周,研究组各项TESS评分均低于对照组,组间差异有统计学意义(P<0.05).结论对精神分裂症顽固性幻听患者采用常规药物联合rTMS治疗,可有效改善患者的精神及幻听症状,安全有效,值得进一步推广应用.
Objective To analyze the clinical effect of conventional drugs combined with low-frequency repetitive transcranial magnetic stimulation(rTMS)in the treatment of intractable auditory hallucinations in schizophrenia Methods The 80 patients with schizophrenia and intractable auditory hallucinations admitted to the hospital from May 2017 to May 2020 were included in the study,and they were divided into two groups using a random number table method,with 40 cases in each group.The control group was treated with conventional drugs combined with rTMS pseudo-stimulation,and the study group was treated with conventional drugs combined with rTMS.Compare the brief psychiatric rating scale(BPRS),clinical global impression(CGI)and audity hallucinations rating scale(AHRS)scores of the two groups before treatment,4,8 and 16 weeks of treatment,the treatment emergent symptom scale(TESS)scores of the two groups before treatment and 16 weeks of treatment were compared.Results At 4,8,and 16 weeks of treatment,the BPRS,CGI and AHRS scores of the study group were lower than those of the control group,and the difference between the groups was statistically significant(P<0.05).At 16 weeks of treatment,all TESS scores in the study group were lower than those in the control group,and the difference between groups was statistically significant(P<0.05).Conclusion For patients with schizophrenia and intractable auditory hallucinations,the use of conventional drugs combined with rTMS can effectively improve the patients'mental and auditory hallucinations.It is safe and effective,and is worthy of further promotion and application.
作者
张颖
张海香
ZHANG Ying;ZHANG Haixiang(Department of Psychiatry,Mental Hospital of Guangzhou Civil Affairs Bureau,Guangzhou Guangdong,510043,China)
出处
《反射疗法与康复医学》
2021年第17期162-165,共4页
Reflexology And Rehabilitation Medicine
关键词
精神分裂症
顽固性幻听
低频重复经颅磁刺激
常规药物
临床效果
Schizophrenia
Intractable auditory hallucination
Low-frequency repetitive transcranial magnetic stimulation
Conventional drugs
Clinical effects
