摘要
目的探究氟哌噻吨美利曲辛片治疗难治性胃食管反流病的临床疗效.方法选取该院2019年9月—2020年9月收治的70例难治性胃食管反流病患者,按照随机数字表法分为试验组与对照组,每组35例.对照组采用雷贝拉唑钠肠溶片联合多潘立酮治疗,试验组在对照组基础上加用氟哌噻吨美利曲辛片治疗.比较两组患者的临床疗效、治疗前后胃肠激素、不良反应发生率.结果试验组治疗总有效率97.14%明显高于对照组的82.86%,差异有统计学意义(P<0.05).治疗后,试验组胃动素、胃泌素水平均明显高于对照组,血管活性肠肽水平明显低于对照组,组间差异有统计学意义(P<0.05).试验组不良反应发生率8.57%高于对照组的5.71%,但差异无统计学意义(P>0.05).结论临床采用氟哌噻吨美利曲辛片治疗难治性胃食管反流病,可提高患者的临床疗效,改善其胃肠激素水平,且用药不良反应少,值得应用.
Objective To explore the clinical efficacy of flupentixol melitracen tablets in the treatment of refractory gastroesophageal reflux disease.Methods A total of 70 patients with refractory gastroesophageal reflux disease admitted to the hospital from September 2019 to September 2020 were selected and divided into an experimental group and a control group according to the random number table method,with 35 cases in each group.The control group was treated with rabeprazole sodium enteric-coated tablets combined with domperidone,and the experimental group was additionally treated with flupentixol melitracen tablets on the basis of the control group.The clinical efficacy,gastrointestinal hormones before and after treatment,and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the experimental group was 97.14%,which was significantly higher than 82.86%in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of motilin and gastrin in the experimental group were significantly higher than those in the control group,and the level of vasoactive intestinal peptide was significantly lower than that in the control group,and the differences between the groups were statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was 8.57%,which was higher than 5.71%in the control group,but the difference was not statistically significant(P>0.05).Conclusion Clinical use of flupentixol melitracen tablets for the treatment of refractory gastroesophageal reflux disease can improve the clinical efficacy of patients,improve their gastrointestinal hormone levels,and less adverse drug reactions,worthy of application.
作者
于莉莉
YU Lili(Department of Gastroenterology,PKUCare Luzhong Hospital,Zibo Shandong,255400,China)
出处
《反射疗法与康复医学》
2021年第9期85-87,共3页
Reflexology And Rehabilitation Medicine
关键词
难治性胃食管反流病
氟哌噻吨美利曲辛片
疗效
胃肠激素
药物不良反应
Refractory gastroesophageal reflux disease
Flupentixol melitracine tablets
Curative effect
Gastrointestinal hormone
Adverse drug reaction
