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The molecular basis of hypertrophic scars 被引量:12

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摘要 Hypertrophic scars(HTS)are caused by dermal injuries such as trauma and burns to the deep dermis,which are red,raised,itchy and painful.They can cause cosmetic disfigurement or contractures if craniofacial areas or mobile region of the skin are affected.Abnormal wound healing with more extracellular matrix deposition than degradation will result in HTS formation.This review will introduce the physiology of wound healing,dermal HTS formation,treatment and difference with keloids in the skin,and it also review the current advance of molecular basis of HTS including the involvement of cytokines,growth factors,and macrophages via chemokine pathway,to bring insights for future prevention and treatment of HTS. Hypertrophic scars(HTS)are caused by dermal injuries such as trauma and burns to the deep dermis,which are red,raised,itchy and painful.They can cause cosmetic disfigurement or contractures if craniofacial areas or mobile region of the skin are affected.Abnormal wound healing with more extracellular matrix deposition than degradation will result in HTS formation.This review will introduce the physiology of wound healing,dermal HTS formation,treatment and difference with keloids in the skin,and it also review the current advance of molecular basis of HTS including the involvement of cytokines,growth factors,and macrophages via chemokine pathway,to bring insights for future prevention and treatment of HTS.
出处 《Burns & Trauma》 SCIE 2016年第1期1-12,共12页 烧伤与创伤(英文)
基金 Authors gratefully acknowledge the support from Li Ka Shine Sino-Canadian Exchange Program(ZZ).This work was also funded by University Hospital foundation from University of Alberta and the Firefighters'Burn Trust Fund
关键词 Hypertrophic scars Animal model CYTOKINES Growth factors MACROPHAGES Stromal cell-derived factor 1/CXCR4 signaling Hypertrophic scars Animal model Cytokines Growth factors Macrophages Stromal cell-derived factor 1/CXCR4 signaling
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