摘要
目的研究讨论糖类抗原125(CA-125)、糖类抗原199(CA-199)、C反应蛋白(CRP)及降钙素原(PCT)在急性胰腺炎(AP)患者中的表达及在AP中的诊治价值.方法选取2012年~2018年芜湖市第一人民医院医院AP患者125例,其中,重症急性胰腺炎组(SAP组)41例、轻症急性胰腺炎组(MAP组)84例,体检健康者30例,分别检测CA-125、CA-199、CRP、PCT,预测上述指标的临床应用价值.结果急性胰腺炎患者中CA-125、CA-199、CRP、PCT均高于对照组,且差异具有统计学意义(P<0.05).SAP组中CA-125、CA-199、CRP、PCT与MAP组比较,差异有统计学意义(P<0.05).对于AP严重程度诊断效能最大的是PCT(敏感性76.68%,特异性84.07%,AUC0.854,其次是CA-199、CA-125、CRP.结论CA-125、CA-199、CRP、PCT的变化与AP的病情严重程度有关,CRP的敏感性最高,而PCT的特异性最强,四种指标对预测AP严重程度具有一定临床价值.
Objective To study the expression of carbohydrate antigen 125(CA-125),carbohydrate antigen 199(CA-199),C-reactive protein(CRP)and procalcitonin(PCT)in patients with acute pancreatitis(AP)and their diagnostic and therapeutic value in AP.Methods 125 patients with AP were selected from Wuhu First People’s Hospital and the First Affiliated Hospital of Anhui Medical University.Among them,41 patients were in severe acute pancreatitis group(SAP group),84 patients were in mild acute pancreatitis group(MAP group),and 30 patients were in physical examination.Results the levels of CA-125,CA-199,CRP and PCT in patients with acute pancreatitis were significantly higher than those in the control group(P<0.05).There was significant difference between sap group and map group in CA-125,CA-199,CRP,PCT(P<0.05).PCT(sensitivity 76.68%,specificity 84.07%,auc0.854),CA-199,CA-125 and CRP were the most effective in the diagnosis of AP severity.Conclusion the changes of CA-125,CA-199,CRP and PCT are related to the severity of AP.The sensitivity of CRP is the highest,while the specificity of PCT is the strongest.
作者
刘浩
LIU Hao(The First People’s Hospital of Wuhu,Wuhu 241000,China)
出处
《肝胆外科杂志》
2020年第2期120-122,共3页
Journal of Hepatobiliary Surgery
关键词
急性胰腺炎
糖类抗原125
糖类抗原199
降钙素原
C反应蛋白
预测价值
acute pancreatitis
carbohydrate antigen 125
carbohydrate antigen 199
procalcitonin
C-reactive protein
predictive value
