CD147与心血管疾病相关研究进展被引量：3

Research progresses in the role of CD147 in cardiovascular diseases

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摘要 CD147是广泛存在于细胞膜表面的一种跨膜糖蛋白,隶属于免疫球蛋白超家族,通过与多种因子结合,广泛参与体内正常的生理代谢和疾病的病理生理过程.最新研究发现,CD147分子在多种心血管疾病如动脉粥样硬化、慢性心力衰竭、扩张型心肌病中均发挥重要作用,其涉及到的信号通路可促进多种心血管疾病的发生发展,而抑制相关信号通路的表达可以改善症状,发挥心血管保护功能,由此可见,CD147可能成为心血管疾病潜在的治疗靶点. CD147,which is a kind of trans-membrane glycoprotein ubiquitously expressed on the cell membrane and belongs to the immunoglobulin superfamily,takes part in the normal physical metabolism and pathogenesis of diseases by recognizing several factors.Recent researches have shown that CD147 plays an important role in many cardiovascular diseases including atherosclerosis,chronic heart failure and dilated cardiomyopathy,and the signaling pathways involved may promote the occurrence and development of many cardiovascular diseases.Moreover,inhibition of the expression of related signaling pathway can improve the symptoms and play a protective role in cardiovascular disease.Thus,CD147 may be a potential therapeutic target for cardiovascular disease.

作者宗枭范骎陶蓉 Zong Xiao;Fan Qin;Tao Rong(Department of Cardiology,Ruijin Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200025,China)

机构地区上海交通大学附属瑞金医院心内科

出处《中华心力衰竭和心肌病杂志（中英文）》 2019年第2期118-121,共4页 Chinese Journal of Heart Failure and Cardiomyopathy

关键词抗原 CD147 心血管疾病 Antigens CD147 Cardiovascular diseases

分类号 R5 [医药卫生—内科学]

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参考文献2

1唐福才,王红艳,马明明,关天旺,潘龙,姚敦琛,陈亚兰,陈玮贝,涂永生,付晓东.CyPA-CD147-ERK1/2-cyclinD2信号通路在大鼠左心室肥厚过程中表达上调(英文)[J].生理学报,2015,67(4):393-400. 被引量：3
2王艺璇,高云涛,崔龙彪,茹凝玉,张海军,焦博,余志斌.他莫昔芬对糖尿病大鼠心肌CD147糖基化与MMPs的影响[J].中国应用生理学杂志,2015,31(1):1-5. 被引量：2

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