摘要
目的 分析炎症性肠病可能发病的危险因素.方法 对207例确诊的炎症性肠病患者(克罗恩病147例,溃疡性结肠炎60例)和414例配对的非炎症性肠病患者进行问卷调查,包括阑尾切除、精神压力、吸烟情况、未成年及成年后吸二手烟情况、饮酒情况等内容,对结果进行统计,以COX回归分析分别筛选出对克罗恩病和溃疡性结肠炎有统计学意义的危险因素,并对各组间情况进行统计描述或χ2检验.结果 COX回归结果显示阑尾切除、精神压力、未成年及成年后吸二手烟在克罗恩病致病因素中有统计学意义;精神压力、未成年吸二手烟在溃疡性结肠炎致病因素中有统计学意义.结论 阑尾切除是克罗恩病的致病危险因素,精神压力和吸二手烟是克罗恩病和溃疡性结肠炎共同的致病危险因素.
Objective To investigate the possible risk factors in the pathogenesis of inflammatory bowel disease using a case-control study. Methods A survey was conducted with 207 inflammatory bowel disease patients(Crohn's disease 147,ulcerative colitis 60)and 414 matching individuals. The questionnaire consisted of the following items,such as appendectomy,mental stress,smoking,exposure to secondhand smoke (childhood,adulthood),drinking alcohol. COX regression analysis was used to select statistically significant risk factors,then description statistics or χ2 test was performed to compare among groups for some items. Results COX regression analysis showed that appendectomy,stress,exposure to secondhand smoke(childhood,adulthood)were risk factors for Crohn's disease while mental stress and exposure to secondhand smoke(childhood) were risk factors for ulcerative colitis. Conclusion Appendectomy is a risk factor for Crohn's disease,mental stress and passive smoking are the risk factors for both Crohn's disease and ulcerative colitis.
出处
《浙江临床医学》
2019年第3期336-338,共3页
Zhejiang Clinical Medical Journal
基金
浙江省医药卫生科技计划资助(2014KYA153).
关键词
炎症性肠病
克罗恩病
溃疡性结肠炎
危险因素
Inflammatory bowel disease
Crohn's disease
Ulcerative colitis
Risk factors
