摘要
目的 探讨血清淀粉样蛋白A(SAA)、B型利尿钠肽(BNP)和降钙素原(PCT)在慢性阻塞性肺病急性加重期(AECOPD)的诊断价值.方法 COPD急性加重期患者87例和COPD稳定期患者64例,分别做痰培养和测定PCT、SAA及BNP.结果 COPD稳定期患者PCT、SAA及BNP检测水平明显低于AECOPD患者(P<0.05);AECOPD组痰培养阳性患者PCT、SAA水平均明显高于COPD稳定组(P<0.01),AECOPD组痰培养阴性患者SAA水平明显高于COPD稳定组(P<0.01);COPD合并心力衰竭患者BNP水平明显高于COPD未合并心力衰竭患者(P<0.01).结论 BNP、PCT和SAA对AECOPD患者均有诊断价值,PCT比SAA在AECOPD的细菌性感染中更有诊断意义,三者检测对AECOPD的诊断和治疗提供临床指导.
Objective To study the detection of serum amyloid protein A(SAA),brain natriuretic peptide(BNP)and procalcitonin(PCT)in chronic obstructive pulmonary disease(COPD)and assess the diagnostic value of acute exacerbation period(AECOPD).Methods 87 cases of patients with acute exacerbation of COPD and 64 patients with COPD were treated in the respiratory department of our hospital.Phlegm culture was performed and PCT,SAA and BNP were measured.Results PCT,SAA and BNP detection levels of COPD stable patients were significantly lower than those of AECOPD patients(P<0.05).The PCT and SAA levels of positive sputum culture patients in the AECOPD group were significantly higher than the COPD stable group(P<0.01),and SAA level in the AECOPD group were significantly higher than COPD stable group(P<0.01).The BNP level of patients with COPD combined with heart failure was significantly higher than patients with COPD uncombined with heart failure(P<0.01).Conclusion BNP,PCT and SAA both have diagnostic value in patients with AECOPD.PCT has more diagnostic value than SAA in bacterial infection during acute exacerbation of COPD.The test provides clinical guidance for the diagnosis and treatment of AECOPD.
出处
《浙江临床医学》
2019年第1期97-98,共2页
Zhejiang Clinical Medical Journal
