摘要
目的 探讨甲状腺激素治疗对亚临床甲状腺功能减退症(SCH)患者动脉粥样硬化的影响.方法 采用随机、双盲、安慰剂对照的临床试验方法.对照组给予安慰剂治疗,观察组给予左旋甲状腺素治疗.观察两组治疗前后颈总动脉后壁内膜中层厚度(IMT)、血液促甲状腺激素(TSH)、游离T3(FT3)、游离T4(FT4)和血脂水平.结果 治疗后,观察组IMT、TSH、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平低于对照组,FT3、FT4水平高于对照组,差异有统计学意义(P<0.05);两组治疗后高密度脂蛋白胆固醇(HDL-C)水平差异无统计学意义(P>0.05).结论 甲状腺素治疗可降低SCH患者TSH水平,提高FT3和FT4水平,改善血脂代谢,逆转动脉粥样硬化,详细作用机制尚有待进一步研究探讨.
Objective To investigate the effect of thyroid hormone on atherosclerosis in patients with subclinical hypothyroidism(SCH).Methods Approved by the hospital ethics committee,a randomized,double-blind,placebo-controlled clinical trial was conducted.The control group was given placebo treatment while the observation group was given levothyroxine treatment.The carotid artery posterior wall intima media thickness(IMT),blood TSH,FT3,FT4 and blood lipid levels of two groups before and after treatment were observed.Results After treatment,the levels of IMT,TSH,TC,TG and LDL-C in the observation group were lower than those of the control group,and the level of FT3 and FT4 was higher than that of the control group(P<0.05),and there was no significant difference in HDL-C levels between the 2 groups after treatment(P>0.05).Conclusion The thyroxine can reduce the level of TSH in SCH patients,improve the level of FT3 and FT4,improve blood lipid metabolism and reverse atherosclerosis.The detailed mechanism of action remains to be further studied.
出处
《浙江临床医学》
2019年第6期797-798,共2页
Zhejiang Clinical Medical Journal
