摘要
目的:探讨布地奈德联合特布他林治疗小儿哮喘的疗效与安全性评价。方法:选取2015年5月—2017年5月我院收治的100例哮喘患儿为研究对象,按照随机数字表法分为两组,各50例。对照组给予常规治疗方案,联合雾化组在常规治疗基础上给予布地奈德(1 mL,雾化吸入,tid)联合特布他林(0.5 mL,雾化吸入,tid)治疗。比较两组哮喘病情控制率,发热、咳嗽、呼吸困难、咳痰消失时间以及不良反应发生率。结果:治疗后联合雾化组发热、咳嗽、呼吸困难、咳痰消失时间短于对照组,差异有统计学意义(P <0.05);联合雾化组哮喘病情控制率高于对照组,差异有统计学意义(P <0.05);两组不良反应发生率比较差异无统计学意义(P> 0.05)。结论:布地奈德联合特布他林治疗小儿哮喘的疗效确切,可有效控制病情,缩短疗程,且安全性好,值得推广。
Objective:To investigate the efficacy and safety of budesonide combined with terbutaline in the treatment of asthma in children.Methods:100 children with asthma admitted to our hospital from May 2015 to May 2017 were selected as subjects investigated and randomly divided into two groups,50 cases each.The children in the control group were given conventional treatment,and the children in the combined nebulization group were given budesonide(1 mL,aerosol inhalation,tid)plus terbutaline(0.5 mL,aerosol inhalation,tid)on the basis of the conventional treatment.The control rate of asthma,the time of fever,cough,dyspnea and expectoration disappearance and the incidence of adverse reactions were compared between the two groups.Results:After treatment,the time of fever,cough,dyspnea and expectoration disappearance in the combined nebulization group was shorter than that in the control group,and the difference was statistically significant(P<0.05).The control rate of asthma in the combined nebulization group was higher than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P<0.05).Conclusion:Budesonide combined with terbutaline is effective in treating asthma in children,which can effectively control the disease and shorten the course of treatment,and has good safety and is worth promoting.
作者
石丰月
马平均
Shi Feng-yue;Ma Ping-jun(Pingdingshan First People’s Hospital,Pingdingshan,Henan 467000 China)
出处
《中国合理用药探索》
CAS
2019年第3期16-18,共3页
Chinese Journal of Rational Drug Use
关键词
布地奈德
特布他林
小儿哮喘
疗效
Budesonide
Terbutaline
Asthma in Children
Efficacy
