摘要
目的:综合分析沙美特罗替卡松吸入治疗缓解期慢性阻塞性肺疾病(慢阻肺)的疗效及对患者肺功能的影响。方法:选取我院2011年2月—2017年3月收治的80例慢阻肺缓解期患者作为研究对象,按照治疗方法的不同分成两组,各40例。对照组单纯应用噻托溴铵(1粒,qd)治疗,试验组在对照组基础上给予沙美特罗替卡松[每次1吸(50μg沙美特罗和100μg丙酸氟替卡松),bid]吸入治疗。比较两组疗效、治疗前后肺功能指标及血气指标。结果:治疗后试验组肺功能指标优于对照组,差异有统计学意义(P <0.05);治疗后试验组氧分压高于对照组,二氧化碳分压低于对照组,差异有统计学意义(P <0.05);试验组临床治疗总有效率为97.50%,高于对照组的80.00%,差异有统计学意义(P <0.05)。结论:沙美特罗替卡松吸入治疗缓解期慢阻肺的疗效显著,可改善患者肺功能指标和血气指标。
Objective:To comprehensively analyze the efficacy of salmeterol and fluticasone inhalation therapy in the treatment of chronic obstructive pulmonary disease(COPD)in remission stage and its effect on lung functions.Methods:80 patients with chronic obstructive pulmonary disease in remission stage admitted to our hospital from February 2011 to March 2017 were selected as subjects investigated and divided into two groups according to different treatment methods,40 cases each.The patients in the control group were treated with tiotropium bromide(1 capsule,qd)alone,and the patients in the experimental group were given salmeterol and fluticasone inhalation therapy[one inhalant per time(50μg salmeterol and 100μg fluticasone propionate),bid]on the basis of the control group.The efficacy,lung function indexes and blood gas indexes before and after treatment were compared between the two groups.Results:After treatment,the lung function indexes in the experimental group were better than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the partial pressure of oxygen in the experimental group was higher than that in the control group,and the partial pressure of carbon dioxide was lower than that in the control group,with statistically significant differences(P<0.05).The total effective rate of clinical treatment in the experimental group was 97.50%,which was higher than 80.00%in the control group,and the difference was statistically significant(P<0.05).Conclusion:Salmeterol and fluticasone inhalation therapy has a significant efficacy in the treatment of chronic obstructive pulmonary disease,which can improve lung function indexes and blood gas indexes.
作者
王昭
徐震
帖永新
Wang Zhao;Xu Zhen;Tie Yong-xin(Respiratory and Critical Disease Discipline 1,Xinxiang Central Hospital,Xinxiang Henan 453000,China)
出处
《中国合理用药探索》
CAS
2019年第2期70-72,76,共4页
Chinese Journal of Rational Drug Use
关键词
沙美特罗替卡松吸入
慢阻肺缓解期
疗效
肺功能
Salmeterol Fluticasone Inhalation
COPD in Remission Stage
Efficacy
Lung Function
