摘要
目的:探究奥美拉唑与铝碳酸镁联合治疗胆囊切除术后胆汁反流性胃炎对患者血清胃肠激素及血管活性肠肽(VIP)、白介素(IL)-6的影响。方法:选取2016年10月—2017年10月我院收治的108例胆囊切除术后胆汁反流性胃炎患者临床资料,依据治疗方案不同分成对照组与研究组,各54例,对照组给予铝碳酸镁(1.0 g,tid)治疗,研究组在对照组基础上加以奥美拉唑(20 mg,qd)治疗,比较两组临床症状积分、血清相关指标及不良反应情况。结果:治疗后两组饱胀、上腹痛、呕吐等症状积分均低于治疗前,且研究组低于对照组,差异有统计学意义(P <0.05);两组VIP、胃泌素、胃动素、IL-6水平优于治疗前,且研究组优于对照组,差异有统计学意义(P <0.05);两组不良反应总发生率比较,差异无统计学意义(P> 0.05)。结论:铝碳酸镁联合奥美拉唑治疗胆囊切除术术后胆汁反流性胃炎可有效降低患者的VIP及IL-6水平,改善胃肠激素水平,缓解临床症状,具推广价值。
Objective:To explore the effect of omeprazole combined with magnesium aluminum carbonate on serum gastrointestinal hormones,vasoactive intestinal peptide(VIP)and interleukin(IL)-6 in patients with bile reflux gastritis after cholecystectomy.Methods:The clinical data of 108 patients with bile reflux gastritis after cholecystectomy admitted to our hospital from October 2016 to October 2017 were selected and divided into a control group and a study group according to different treatment regimens,54 cases each.The patients in the control group were given aluminum magnesium carbonate(1.0 g,tid)treatment,and the patients in the study group were treated with omeprazole(20 mg,qd)on the basis of the control group.The clinical symptom scores,serum related indicators and adverse reactions were compared between the two groups.Results:The scores of symptoms such as fullness,upper abdominal pain and vomiting after treatment were lower than those before treatment,and the scores in the study group were lower than those in the control group,with statistically significant differences(P<0.05).The levels of VIP,gastrin,motilin and IL-6 in the two groups after treatment were better than those before treatment,and the levels in the study group were better than those in the control group,with statistically significant differences(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions(P>0.05).Conclusion:Magnesium aluminum carbonate combined with omeprazole in the treatment of postoperative cholecystectomy for bile reflux gastritis can effectively reduce the levels of VIP and IL-6,improve the levels of gastrointestinal hormones and relieve clinical symptoms,and has promotion value.
作者
李宁
Li Ning(People’s Hospital of Queshan County,Zhumadian Henan 463200,China)
出处
《中国合理用药探索》
CAS
2019年第2期31-34,共4页
Chinese Journal of Rational Drug Use
关键词
奥美拉唑
胆囊切除术
胆汁反流性胃炎
铝碳酸镁
血清胃肠激素
Omeprazole
Cholecystectomy
Bile Reflux Gastritis
Magnesium Aluminum Carbonate
Serum Gastrointestinal Hormone
