摘要
目的:探讨急性冠脉综合征患者经皮冠状动脉介入术(PCI)治疗后应用瑞舒伐他汀对其心功能及心肌损伤的影响.方法:选择我院2015年10月—2018年10月收治的80例急性冠脉综合征患者,按随机数字表法分为两组,各40例.对照组给予阿托伐他汀钙片(40 mg,qd)治疗,观察组给予瑞舒伐他汀钙片(20 mg,qd)治疗,比较两组炎症因子、心功能指标.结果:治疗后,观察组脑尿钠肽(BNP)、超敏C反应蛋白(hs-CRP)、肌钙蛋白(cTnI)、磷酸肌酸激酶(CK-MB)及乳酸脱氢酶(LDH)水平均低于对照组,差异有统计学意义(P<0.05);观察组左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)均较对照组低,且左室射血分数(LVEF)较对照组高,差异有统计学意义(P<0.05).结论:急性冠脉综合征患者 PCI 术后给予瑞舒伐他汀治疗,可有效改善患者炎症因子及心肌损伤,提高心功能,促进术后疾病转归.
Objective:To investigate the effect of rosuvastatin on cardiac functions and myocardial injury in patients with acute coronary syndromes after percutaneous coronary intervention(PCI).Methods:80 patients with acute coronary syndromes admitted to our hospital from October 2015 to October 2018 were selected and randomly divided into two groups,40 cases each.The patients in the control group were treated with atorvastatin calcium tablets(40 mg,qd),and the patients in the observation group were treated with rosuvastatin calcium tablets(20 mg,qd).The inflammatory factors and cardiac function indexes were compared between the two groups.Results:After treatment,the levels of brain natriuretic peptide(BNP),hypersensitive C-reactive protein(hs-CRP),troponin(cTnI),phosphocreatine kinase(CK-MB)and lactate dehydrogenase(LDH)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The left ventricular end-systolic diameter(LVESD)and left ventricular end-diastolic diameter(LVEDD)in the observation group were lower than those in the control group,while the left ventricle ejection fraction(LVEF)was higher than that in the control group,with statistically significant differences(P<0.05).Conclusion:Rosuvastatin treatment can effectively improve inflammatory factors and myocardial injury,improve cardiac functions and promote postoperative disease outcomes in the patients with acute coronary syndromes after PCI.
作者
井河江
Jing he-jiang(Department of Cardiology,Nanyang Second People’s Hospital Nanyang Henan 463000,China)
出处
《中国合理用药探索》
CAS
2019年第6期44-46,共3页
Chinese Journal of Rational Drug Use
