摘要
目的:观察胸腔闭式引流后注入香菇多糖联用博来霉素及单用博来霉素治疗晚期肺癌伴恶性胸腔积液的疗效以及毒副反应。方法选择120例晚期肺癌伴恶性胸腔积液的住院患者,用中心静脉导管行胸腔内置管及引流胸液,胸腔内分别注入香菇多糖和博来霉素及单用博来霉素。结果香菇多糖联和博来霉素有效[完全缓解(CR)+部分缓解(PR)]率为81.6%,明显优于单用博来霉素组48.3%(P<0.05)。结论胸腔闭式引流并灌注香菇多糖联和博来霉素治疗晚期肺癌恶性胸腔积液的疗效优于单用博来霉素,效果确切。
Objective To compare the ef ect of lentinan(LNT)combined with bleomycin(BLM)and bleomycin(BLM)alone in the treatment of anvanced lung cancer combining malignant pleural ef usion by thoracic cavity perfusion drainage.Methods One hundred and twenty patients with anvanced lung cancer bombining malignant pleural ef usion were applied with the cavity central venous catheters,then randomized to receive bleomycin and lentinan injected intrapleural y or bleomycin alone.Results The ef ective rate of 81.6%in the research group was higher than that of 48.3%in the control group(<0.05).Conclusion Afterdraining completely the pleural ef usion,the intracavity injection of letinan and bleomycin is more ef ective fir the treatment of anvanced lung cancer bombining malignant pleural ef usion.
作者
廖敏
陈燕
LIAO Min;CHEN Yan(Department of Respiration,Xiangya No.2 Hospital of Central South University,Changsha 410011,Hunan,China)
关键词
香菇多糖
恶性胸腔积液
博来霉素
胸腔闭式引流
Letinan(LNT)
Malignant pleutal ef usion
Close thoracic drainage
Bleomycin(BLM)
