摘要
目的比较丙泊酚和七氟醚对老年患者术后早期认知功能的影响。方法筛选年龄≥65岁,ASAⅠ~Ⅱ级的患者62例行择期胸腹部手术,随机分为丙泊酚组和七氟醚组,每组31例。患者术前及术后6 h、12 h、24 h和48h均采用MMSE评价认知功能。结果术后6h、12h、24h丙泊酚组和七氟醚组MMSE评分比较,差异显著(P<0.05),且随时间的延长,POCD得到改善,术后48 h ,基本恢复正常。结论丙泊酚和七氟醚均可降低老年患者术后早期的认知功能,但七氟醚比丙泊酚认知功能恢复快。
Objective To compare the ef ects of propofol and sevoflurane on early cognitive function for elderly patients.Methods 62 patients over the age of 65,ASAⅠ~II,and thoracic and abdominal operation were screened,they were divided into propofol group and sevoflurane group,each group had 31 cases.Pre-and postoperative in 6 h,12 h,24h and 48h conditions of patients as wel as MMSE were rated.Results Patients were used propofol and sevoflurane with 6h,12h,24h hours,Their MMSE score had significant dif erence(<0.05),and with the extension of time,POCD could be improved and got back to normal after 48h.Conclusion Propofol and sevoflurane could reduce the early cognitive function for elderly patients,but cognitive function recovered more quickly for sevoflurane than propofol.
作者
肖玉波
XIAO Yu-bo(Department of Anesthesiology,The Second People's Hospital of Weifang City,Weifang 261041,Shandong,China)
关键词
丙泊酚
七氟醚
术后认知功能障碍
Propofol
Sevoflurane
Postoperative cognitive dysfunction
