摘要
目的:探讨金黄色葡萄球菌临床分离株对红霉素和克林霉素的耐药性及红霉素对克林霉素诱导耐药分析。方法采用纸片扩散方法测定金黄色葡萄球菌对红霉素和克林霉素的耐药性,并以D-试验法测定红霉素对克林霉素的诱导耐药表型。结果189株金黄色葡萄球菌中耐甲氧西林135株占71.43%,甲氧西林敏54株占28.57%。红霉素和克林霉素均耐药的105株占55.56%,红霉素和克林霉素均敏感19株占10.05%,红霉素耐药而克林霉素敏感65株占34.39%。对红霉素耐药而克林霉素敏感的MRSA和MSSA诱导耐药发生率分别为62%和66.67%。结论检测金黄色葡萄球菌中克林霉素诱导性耐药可以指导临床医师合理选用抗菌药物。
Objective To investigate the clinical isolates of Staphylococcus aureus resistance to erythromycin and clindamycin and erythromycin and clindamycin-induced resistance analysis.By disk dif usion method for determining.Methods Aureus to erythromycin and clindamycin resistance,and D-test method for the determination of erythromycin inducible clindamycin resistance phenotype.Results 189 Staphylococcus aureus resistant to methicil in 135 accounted for 71.43%,methoxy Xilin Min 54(28.57%).Erythromycin and clindamycin are resistant to 105 representing 55.56%were sensitive to erythromycin and clindamycin 19 accounted for 10.05%,while resistance to erythromycin and clindamycin-sensitive 65 accounted for 34.39%.Resistant to erythromycin and clindamycin-sensitive MRSA and MSSA incidence of induced resistance was 62%and 66.67%,respectively.Conclusion The detection of Staphylococcus aureus resistant to clindamycin-induced clinicians can guide rational use of antimicrobial drugs.
作者
夏琼芳
XIA Qiong-fang(Clinical Laboratory,The Third Hospital of Yueyang City,Yueyang 414000,Hunan,China)
关键词
金黄色葡萄球菌
红霉素
克林霉素
耐药率
诱导耐药
Staphylococcus aureus
Erythromycin
Clindamycin
Resistance rates
Induce resistance
