摘要
目的观察总IgE与嗜酸粒细胞阳离子(ECP)在鼻息肉患者血浆中的水平,探讨IgE介导的I型变态反应在鼻息肉发生、发展和复发中的作用。方法43例变应性鼻炎、80例慢性鼻窦炎不伴鼻息肉、80例鼻息肉与60例健康对照志愿者作为本次研究对象。检测受试对象血清嗜酸性粒细胞阳离子蛋白(ECP)水平与血清IgE的水平。结果鼻息肉患者血清IgE和ECP水平明显高于对照组(均<0.01)和外周血(均<0.01);鼻息肉患者外周血中IgE和ECP水平与对照组相比差异无显著性(均>0.05)。结论鼻息肉是以嗜酸性粒细胞浸润为特征的疾病过程,IgE介导的I型变态反应在鼻息肉形成过程中发挥一定作用。
Objective To evaluate the level of total IgE(TigE)and Eosinophilic Cationic Protein(ECP)concentration in the plasma of patients with nasal polyp and to investigate the mechanisms of IgE-mediated type I al ergy in the onset,development,and recurrence of nasal polyps.Methods To detect the serum TigE and ECP expression levels in 43 cases of al ergic rhinitis(AR),80 cases of chronic rhinosinusitis(CRS),80 cases of nasal polys(NP)and 60 cases of healthy volunteers.Results The TigE and ECP expression levels in patients with nasal polyp were higher than those in control groups(﹤0.01)and in serum(﹤0.01).The serum TigE and ECP levels in patients with nasal polyp were not significantly dif erent from those in control groups(﹥0.05).Conclusion Nsal polyp is a disease characterized by eosinophile granulocyte infiltrating,and IgE-mediated type I al ergy may play a role in the formation of nasal polyp.
作者
胡志红
高俊玲
孔祥玉
HU Zhi-hong;GAO Jun-ling;KONG Xiang-yu(Basic Medical College of Hebei United University,Tangshan 063000,Hebei,China)
