摘要
目的:通过分析承德地区幽门螺杆菌(helicobacter pylori,H .pylori)临床分离珠对多种抗菌药物的敏感性,指导临床对于 H pylori根除治疗时的药物选择,提高根除率。方法用Kirby-Bauer药敏纸片法对108珠H pylori分别进行9种抗生素的药敏试验,并对药敏结果进行分析,得出相应的结果。结果 H pylori对阿莫西林/克拉维酸钾、阿莫西林的敏感率为100%,对甲硝唑、呋喃唑酮、克拉霉素、左氧氟沙星、四环素、米诺环素、氨苄西林的敏感率为76.9%、18.5%、9.3%、40.7%、8.3%、11.1%、37.8%。结论承德地区H pylori对阿莫西林/克拉维酸钾、阿莫西林、克拉霉素的敏感率高,可推荐为临床首选药物。对甲硝唑、左氧氟沙星、氨苄西林敏感率较低,不建议常规使用。
Objective Through the analysis of clinical isoates of helicobacter pylori(H pylori)Chengde beads antimicrobial susceptibility to a variety of clinical drug of choice for treatment of H pylori eradication,to improve eradication rates.Methods Susceptibility using the Kirby-auer disk dif usion method against 108 clincial isolates of H pylori pearl beads were performed in nine of antimicrobial susceptibility testing,and analyze the results.Results The profit sensitivity rate of H pylori to amocxicil in/ciavulanate、amoxicil in were100%to metronidazole、furazolidone、clarithromycin、levpfloxacin、minocycline、tetracycline a-nd ampicil in was76.9%、18.5%、9.3%、40.7%、8.3%、11.1%、37.8%.Concluion Chengde H pylori amoxicil ion/clavulanate potassium,amoxicil in sensitive rate,can be recommend-ed for clinical drug of choice,mertonidazole、levofloxacin、minocycline sensitive lower rate,was not recommended for routine use.
作者
李立文
孙学慧
李建辉
LI Li-wen;SUN Xue-hui;LI Jian-hui(Chengde City Central Hospital,Chengde 067000,Hebei,China)
关键词
承德地区
幽门螺杆菌
药敏试验
耐药性
Chengdearea
Drug sensitive test
Antibiotic resistance
Hilicobacter pylori
