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p53基因第72密码子多态性与肿瘤关系的研究

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摘要 p53基因是迄今发现与人类肿瘤发生相关性最高的基因之一,具有野生型和突变型两种。野生型基因在保持基因的完整性和抑制细胞恶变的过程中起着重要作用,当野生型基因发生突变时具有促肿瘤作用,大约50%的人类癌症中存在着p53基因的突变。 p53基因具有多态性,其第72位密码子的CGC/CCC是一个常见的多态位点,研究发现p53基因第72位密码子Arg/Pro多态与多种恶性肿瘤的遗传易感性有关。
出处 《医学信息(医学与计算机应用)》 2014年第14期643-643,644,共2页 Medical Information
基金 青海省科学自然基金(2012-Z-908)。
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