摘要
目的探讨不同剂量米非司酮应用于妇科肿瘤的效果,以供参考。方法将我院妇科2010年6月~2013年5月收治的子宫肌瘤患者95例纳入本研究,根据随机原则分组。对照组患者接受常规剂量米非司酮治疗,实验组患者接受小剂量米非司酮治疗。观察两组治疗前后在子宫肌瘤体积、血清生殖激素水平等方面的变化,并对比治疗期间不良反应的差异性。结果与治疗前比较,两组患者治疗后子宫肌瘤体积明显缩小,E2、FSH、P、LH等激素水平明显下降,差异经统计学分析后认为有意义(约0.05)。治疗后各指标组间差异统计学分析后认为无意义(跃0.05)。与对照组对比,我们发现实验组患者治疗期间不良反应发生率明显较低,组间差异经统计学分析后认为有意义(约0.05)。结论常规剂量与小剂量米非司酮用于治疗子宫肌瘤均具有良好的疗效,其中小剂量米非司酮不良反应发生率更低,今后可将其进行临床推广应用。
Objective Investigate the application of dif erent doses of mifepristone in gynecological tumor,for reference.Methods Choose 95 patients from Jun.2010 to May.2013 in this study,random grouping.Control group received routine dose of mifepristone treatment,experimental group received low dose mifepristone treatment.Observe the changes in the size of myoma of uterus,serum reproductive hormone levels and other aspects of the two groups before and after treatment,and compared the difference of adverse reactions during treatment.Results Compared with before treatment,two groups of patients after the treatment of uterine myoma volume was significantly reduced,E2,FSH,P,LH and other hormone levels decreased,difference had statistics significance(<0.05).After treatment,dif erence between the groups of indicators had no significance(>0.05).Compared with control group,the adverse reaction rate in experimental group were lower,differences between groups were analyzed statistical y significant(<0.05).Conclusion Conventional dose and smal dose of mifepristone for treatment of uterine fibroids have good curative effect,and adverse reactions of low dose mifepristone lower incidence,can be clinical applicated in the future.
作者
熊黎
XIONG Li(Department of Gynaecology and Obstetrics,Maternal and Child Health Hospital of Hunan Province,Changsha 410000,Hunan,China)
关键词
米非司酮
妇科肿瘤
应用效果
Mifepristone
Gynecological tumor
Application ef ect
