摘要
目的:系统地介绍生物隔离材料预防粘连的基础研究以及目前国内市场上防粘连产品的临床研究。方法查阅近年来国内有关防粘连的基础和临床研究文献,对文献进行综述总结。结果组织粘连常发生在外科手术后,它能够引起多种临床并发症,影响器官的正常功能,目前临床使用生物隔离材料防治手术后粘连,其中聚乳酸、透明质酸和壳聚糖是国内最为广泛研究和应用的材料。结论目前手术防粘连产品可以防止手术后粘连的发生,但存在许多局限之处,生物凝胶材料有望成为新型手术防粘连医疗产品。
Objective To introduce basic and clinical studies of the anti-adhesion products in current domestic market.Methods The domestic literatures related to basic and clinical studies of anti-adhesion in recent years were reviewed.Results Postoperative adhesion often occurs after surgeries in clinic.It causes a variety of clinical complications and af ects the normal function of injured organs.Currently a number of materials are used in clinic to prevent postoperative adhesion.Polylactic acid,hyaluronic acid and chitosan are the most widely investigated and used materials.Conclusions The current products can prevent adhesion formation after surgeries.But there are many weaknesses.Hydrogel could become a new generation of anti-adhesion product.
作者
张会会
原芳
孙雨龙
ZHANG Hui-hui;YUAN Fang;SUN Yu-long(Chinese Academy of Sciences Shenzhen Institutes of Advanced Technology,Shenzhen Guangdong 518055,China)
关键词
外科手术
粘连
国内防粘连产品
Surgery
Adhesion
Domestic Anti-adhesion Products
