摘要
Objective: To study the effect of Ginkgo Biloba extract combined with butylphthalide on serum biochemical indexes of patients with mild to moderate Alzheimer's disease. Methods:The patients who were diagnosed with mild to moderate Alzheimer's disease for the first time in Weinan Central Hospital between March 2015 and December 2017 were selected as the research subjects and randomly divided into two groups, observation group received Donepezil Hydrochloride Tablets + Ginkgo Biloba Extract Tablets + Butylphthalide Soft Capsules treatment, and control group received Donepezil Hydrochloride Tablets treatment. The serum levels of metabolites, cytokines, oxidative stress mediators and other biochemical indicators were measured before treatment and 3 months after treatment. Results: 3 months after treatment, serum Hcy, IL-1β, TNF-α, HMGB1, MCP-1, MDA and Tau levels of both groups of patients were significantly lower than those before treatment whereas UA, VitB12, FA, VEGF, BDNF, GPX3, CAT and SOD levels were significantly higher than those before treatment, and serum Hcy, IL-1β, TNF-α, HMGB1, MCP-1, MDA and Tau levels of observation group after treatment were significantly lower than those of control group whereas UA, VitB12, FA, VEGF, BDNF, GPX3, CAT and SOD levels were significantly higher than those of control group. Conclusion: Ginkgo Biloba extract combined with butylphthalide treatment of mild to moderate Alzheimer's disease can significantly improve the substance metabolism and reduce the inflammatory stress response.
