摘要
Objective:To investigate the clinical assessment of thyroid carcinoma in acoustic pulse radiation imaging and the correlation analysis of osteopontin expression.Methods: A total of 71 lesions of 60 patients with thyroid carcinoma (TC) in Hainan were selected. All patients were graded by TI-RADS grading and confirmed by pathology after operation. The expression of OPN was detected by immunohistochemical S-P method. The expression of OPN mRNA was detected by fluorescence quantitative polymerase chain reaction. The correlation between OPN expression and acoustic pulse radiation imaging was analyzed.Results:(1) 60 patients (93.33%) with primary TC and 4 (6.67%) patients with secondary TC were found in 60 patients with TC. Thirty-seven patients (61.67% according to the pathological features, 32 cases (53.33%) had papillary TC, diffuse sclerosis 19 cases of diffuse sclerosis PTC (31.67%), follicular carcinoma in 9 cases (15.00%). (2) The expression of OPN mRNA in 37 cases of calcified TC was significantly higher than that in non-calcified TC, and the increase of OPN expression was in direct proportion to the distribution of gritty calcification.Conclusions: The distribution of calcified microsomes in TC was positively correlated with the expression of OPN, suggesting that enhanced OPN expression may be related to the formation of psammoma bodies, the increased hardness of nodules and the increased malignancy. Acoustic pulse radiation imaging technology for early diagnosis of TC and prognosis of TC was of great significance.
