摘要
Objective: To investigate the effects of dezocine on postoperative stress response and immune function in patients with breast cancer. Methods: According to random data table method, a total of 80 patients who were scheduled for breast cancer radical surgery from September 2016 to May 2017 were divided into observation group and the control group, 40 cases in each group. The observation group gave intravenous injection of dezocine as an advanced analgesia 15 min before anesthesia induction, the control group given the same amount of sodium chloride injection. The levels of serum inflammatory factors and immune function were measured and compared between the two groups before and after operation. Results: The levels of angiotensin Ⅱ, renin, cortisol, aldosterone, CD3+, CD4+, CD8+and CD4+/CD8+ in the two groups before treatment were not statistically significant. The levels of angiotensin Ⅱ, renin, cortisol, aldosterone in the two groups were increased at first and then decreased, which were significantly higher than those in the same group before operation at 1 d and 3 d;and the levels of angiotensin Ⅱ, renin, cortisol, aldosterone in the observation group were significantly lower than those in the control group after 1 d and 3 d, the difference was statistically significant. The levels of serum CD3+, CD4+ and CD4+/CD8+ in the two groups were decreased at first and then increased, which were significantly lower than those in the same group before operation at 1 d and 3 d;and the observation group levels were significantly higher than those in the control group after 1 d and 3 d, the above indicators were compared with the difference was statistically significant. The levels of serum CD8+ in the two groups were increased at first and decreased subquently, which were significantly higher than those in the same group before operation at 1 d and 3 d and the observation group levels were significantly lower than those in the control group after 1 d and 3 d, the above indicators were compared with the difference was statistically significant. The above indicators have restore to preoperative levels after 5 d. Conclusion: Dezocine can reduce the stress response in patients with perioperative breast cancer, improve the immune function of patients, which has important clinical value, so it is worth promoting.
